Polymeric carrier

1. A polymeric carrier comprising:

(a) a plurality of polymers that are block copolymers assembled into a polymeric carrier, the polymeric carrier comprising a core and a shell, the block copolymers having the chemical Formula I:

wherein

each of A 0 , A 1 , A 2 , A 3 and A 4 is —C—C—;

Y 0 is —C(O)O(1C-10C)alkyl-, optionally substituted with one or more fluorine groups;

Y 1 is —C(O)O(2C-10C)alkyl-;

Y 2 is —C(O)OCH 2 CH 2 —;

Y 3 is a covalent bond;

Y 4 is —C(O)O(CH 2 ) 3 CH 3 ;

wherein tetravalent carbon atoms of A 0 -A 4 that are not fully substituted with R 1 -R 5 and Y 0 -Y 4 are completed with an appropriate number of hydrogen atoms;

R 1 is (1C-3C)alkyl;

each of R 2 , R 3 , and R 5 is —CH 3 ;

R 4 is —CH 2 CH 2 CH 3 ;

Q 0 is a pyridyl disulfide residue;

Q 1 is a residue selected from the group consisting of polyoxylated alkyl, polyethylene glycol, and polypropylene glycol;

Q 2 is a dimethylamino residue;

Q 3 is a carboxyl residue;

m is greater than 0 to less than 1.0;

n is greater than 0 to less than 1.0, wherein m+n=1;

p is 0.1 to 0.9;

q is 0.1 to 0.9;

r is 0 to 0.8 wherein p+q+r=1;

v is 1 to 25 kDa; and

w is 1 to 50 kDa; and

(b) at least one polynucleotide,

wherein the polynucleotide is not in the core of the polymeric carrier.

2. The polymeric carrier of claim 1 , wherein the at least one polynucleotide is an oligonucleotide.

3. The polymeric carrier of claim 1 , further comprising a targeting moiety.

4. The polymeric carrier of claim 1 , wherein the targeting moiety is attached to the shell portion by a covalent bond to a polymer.

5. The polymeric carrier of claim 1 , wherein the plurality of polymers have spontaneously self-assembled into the polymeric carrier.

6. The polymeric carrier of claim 1 , wherein the shell of the polymeric carrier comprises the polynucleotide.

7. The polymeric carrier of claim 1 , wherein the at least one polynucleotide is attached to the block copolymer by a covalent bond, a non-covalent interaction, or a combination thereof.

8. The polymeric carrier of claim 1 , wherein the polynucleotide is an siRNA.

9. A composition comprising the polymeric carrier of claim 1 .

10. The polymeric carrier of claim 1 , wherein Q 1 is a polyethylene glycol residue.

11. The polymeric carrier of claim 1 , wherein

Y 1 is —C(O)OCH 2 CH 2 —.

12. The polymeric carrier of claim 1 , wherein

Y 0 is —C(O)OCH 2 CH 2 —.

13. The polymeric carrier of claim 1 , wherein v is 5 to 25 kDa.