Non-reactive adhesive useful in transdermal drug delivery system
An adhesive composition which lacks functional groups containing reactive hydrogen moieties and contains no post-polymerization chemical crosslinker finds use in transdermal drug delivery systems. The invention enables the administration of drugs containing a reactive functional group, which drugs have heretofore not been able to be administered by the transdermal route using conventional acrylic adhesives.
1. A composition consisting of
an adhesive polymer prepared from a mixture of monomers consisting of:
about 45 wt %, based on the total monomer weight, of 2-ethyl hexyl acrylate, about 35 wt %, based on the total monomer weight, of methyl acrylate, and about 20 wt %, based on the total monomer weight, of t-octylacrylamide, dimethyl acrylamide, isopropyl acrylamide, or vinyl acetamide;
a therapeutic agent that is a non-salt; and
at least one ingredient selected from the group consisting of enhancer, plasticizer, tackifying agent, viscosity modifier, excipient, diluent, emollient, anti-irritant, opacifier, pigment, and preservative, wherein the composition is a transdermal composition.
2. The composition of claim 1 , wherein the mixture of monomers consists of 45 wt % of 2-ethylhexyl acrylate, 35 wt % of methyl acrylate and 20 wt % of t-octyl acrylamide.
3. The composition of claim 1 , wherein the therapeutic agent is fentanyl.