Hyperspectral/multispectral imaging in determination, assessment and monitoring of systemic physiology and shock
The present invention provides a hyperspectral imaging system which demonstrates changes in tissue oxygen delivery, extraction and saturation during shock and resuscitation including an imaging apparatus for performing real-time or near real-time assessment and monitoring of shock, including hemorrhagic, hypovolemic, cardiogenic, neurogenic, septic or burn shock. The information provided by the hyperspectral measurement can deliver physiologic measurements that support early detection of shock and also provide information about likely outcomes.
1. An apparatus for evaluating a local tissue of a subject, the apparatus comprising:
an optical acquisition system configured to generate medical hyperspectral imaging data of a region of interest of the subject, wherein the optical acquisition system has a first field-of-view;
a diagnostic processor that receives the medical hyperspectral imaging data from the optical acquisition system;
at least one algorithm running on the diagnostic processor, wherein the at least one algorithm uses at least one of oxygenated, deoxygenated, and total hemoglobin levels based on the medical hyperspectral imaging data to quantify a clinical signal of the local tissue of the subject;
a display device configured to display the quantified clinical signal of the local tissue of the subject; and
an image projector having a second field-of-view that is precisely co-aligned with the first field-of-view, wherein the image projector projects a fiducial self-calibration pattern and the generated medical hyperspectral imaging data onto the region of interest in a visible spectrum wavelength range, wherein
the optical acquisition system is configured to read the fiducial self-calibration pattern projected onto the region of interest in order to achieve co-registration between the first field of view and the second field of view and map the generated medical hyperspectral imaging data onto the region of interest.
2. The apparatus of claim 1 , wherein the optical acquisition system comprises a digital camera that comprises a charge-coupled device element and a lens.
3. The apparatus of claim 1 , wherein the optical acquisition system comprises a visible-wavelength, liquid-crystal tunable filter.
4. The apparatus of claim 1 , wherein the optical acquisition system comprises a NIR-wavelength, liquid-crystal tunable filter.
5. The apparatus of claim 1 , wherein the optical acquisition system comprises a filter that has the capacity to filter both visible and NIR light.
6. The apparatus of claim 1 , wherein the optical acquisition system comprises a visible filter and an NIR-wavelength, liquid-crystal tunable filter.
7. The apparatus of claim 1 , wherein the optical acquisition system comprises a visible-wavelength, liquid-crystal tunable filter and a narrow band IR illumination source.
8. The apparatus of claim 1 , wherein the optical acquisition system comprises a visible-wavelength, liquid-crystal tunable filter and one or more infrared filters.
9. The apparatus of claim 1 , wherein the optical acquisition system comprises a digital camera having a CMOS element and a lens.
10. The apparatus of claim 1 , wherein the optical acquisition system comprises an acousto-optical tunable filter.
11. The apparatus of claim 1 , wherein the optical acquisition system comprises a switchable filter array.
12. The apparatus of claim 1 , wherein the optical acquisition system comprises a filter, wherein one or more selected wavelengths of light are delivered from a light source into the filter.
13. The apparatus of claim 12 , wherein the one or more selected wavelengths of light comprise NIR wavelengths.
14. The apparatus of claim 12 , wherein the one or more selected wavelengths of light comprise visible wavelengths.
15. The apparatus of claim 12 , wherein the one or more selected wavelengths of light comprise visible wavelengths and NIR wavelengths.
16. The apparatus of claim 12 , comprising a filter coupled to a front of the optical acquisition system.
17. The apparatus of claim 1 , wherein the optical acquisition system comprises a power supply and an illuminator that supplies coaxial or near-coaxial illumination, the power supply powering the illuminator.
18. The apparatus of claim 1 , further comprising a software program configured to control the diagnostic processor.
19. The apparatus of claim 1 wherein the apparatus is portable.
20. The apparatus of claim 1 wherein the acquisition of medical hyperspectral imaging data by the optical acquisition system is performed in real-time or near real-time.
21. The apparatus of claim 1 , wherein the optical acquisition system comprises at least two optical stages.
22. The apparatus of claim 1 , wherein the optical acquisition system comprising at least one polarizer.
23. The apparatus of claim 1 , wherein an outputted status of the subject, by the display device, comprises a visual signal.