Gastrointestinal capsule
An ingestible gastrointestinal capsule (GIC) for mechanically stimulating a segment of the gastrointestinal (GI) wall by alternately and repeatedly pressurizing, and/or vibrating it is provided. The GIC is programmed to being activated following a predefined time delay. The activated GIC agitates, shakes, rattles, jolts, vibrates and/or moves in a reciprocal expanding and contracting motion thereby mechanically stimulating the adjacent segment of the GI wall at a targeted location. Activation of the GIC may include a number of automatically accomplished partial activations, such as when the time elapsed from the moment of setting the GIC on equals a predefined time delay; when the mechanical load applied onto the GIC exceeds, and/or gets lower than a respective predefined level of mechanical load; when the ambient pH reaches a predefined level, or changes, and/or a temperature associated with the user reaches a predefined threshold. Agitation is accomplished by means of agitation means embedded in the GIC. Such agitation means includes an unbalanced weight attached to the shaft of an electric motor, an actuator implemented by, such as an electric solenoid, an electro-active polymer (EAP), a dielectric elastomer actuator (DEA), embedded in a GIC of the invention.
1. A gastrointestinal capsule (GIC) comprising: (a) a segmented hollow shell including first and second members; (b) a battery housed within the capsule; (c) a vibrating agitation mechanism housed within the capsule and powered by said battery, said vibrating agitation mechanism adapted to effect a vibrating movement by reciprocating said first member in an opposite direction with respect to said second member; and the gastrointestinal capsule adapted to transit an alimentary canal of a human.
2. The gastrointestinal capsule according to claim 1 , wherein at least one resilient spike being attached to a surface of said hollow shell, and said at least one resilient spike being made of biodegradable material.
3. The gastrointestinal capsule according to claim 1 , wherein said vibrating agitation mechanism being operative in a sensing mode and in an agitation mode, and wherein a power exerted by said vibrating agitation mechanism is of higher magnitude in said agitation mode compared to a power exerted by said vibrating agitation mechanism in said sensing mode.
4. The gastrointestinal capsule according to claim 1 , said vibrating agitation mechanism adapted such that when disposed within a gastrointestinal tract of said human, in an agitation mode, said vibrating agitation mechanism effects a mechanical excitation of a wall of said tract.
5. The gastrointestinal capsule according to claim 1 , said vibrating agitation mechanism being adapted such that when disposed within a gastrointestinal tract of said human, in an agitation mode, said vibrating agitation mechanism induces a peristaltic wave in a wall of said tract.