IP Library › Granted Patent US 9,079,936
Granted Patent B2
US 9,079,936 · App. 12/543,455 · Granted Jul 14, 2015

Derivatives of APF and methods of use

Inventors: Susan K. Keay (Ellicott City, MD); Christopher Michejda (North Potomac, MD); Zoltan Szekely (Frederick, MD)
Assignees: University of Maryland, Baltimore; The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services; The United States of America as Represented by the Department of Veterans Affairs
C07K9/005A61K38/00
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Quick Facts
Patent No.
US 9,079,936
App. No.
12/543,455
Granted
Jul 14, 2015
Kind
B2
Abstract

Derivatives of a novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits and reagents, and methods of using the compounds for identifying and/or treating interstitial cystitis and cancer are disclosed. In particular embodiments, the glycopeptide comprises D-proline.

Claims (4)

1. A composition comprising two sugars and a peptide that comprises SEQ ID NO:11, wherein the sugars are β-galactose and N-acetyl galactosamine that are linked to each other, wherein the N-acetyl galactosamine is linked to the peptide in the alpha configuration.

2. A kit, comprising the composition of claim 1 .

3. The composition of claim 1 , further comprising a delivery vehicle.

4. The composition of claim 1 , comprised in a pharmaceutically acceptable excipient.

Assignments (6)
ASSIGNMENT OF JOINT UNDIVIDED RIGHT, TITLE AND INTEREST Recorded May 2, 2012
From: UNIVERSITY OF MARYLAND, BALTIMORE
To: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPT OF VETERANS AFFAIRS
Reel/Frame 028140/0429 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 8, 2011
From: MICHEJDA, CHRISTOPHER; SZEKELY, ZOLTAN
To: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
Reel/Frame 025759/0641 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 8, 2011
From: VEENSTRA, TIMOTHY D.
To: GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Reel/Frame 025759/0781 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 8, 2011
From: CONRADS, THOMAS P.
To: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Reel/Frame 025759/0904 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 7, 2011
From: KEAY, SUSAN K.
To: UNIVERSITY OF MARYLAND, BALTIMORE, THE
Reel/Frame 025754/0485 →
CONFIRMATORY LICENSE Recorded Aug 24, 2009
From: UNIVERSITY OF MARYLAND BALT PROF SCHOO
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 023136/0444 →
Continuity (3)
Continuation In Part 11955755 · Dec 13, 2007
Continuation 11743865 · May 3, 2007
Related Publication 20100041588A1 · Feb 18, 2010