Endoscopic hemostatic clipping apparatus

1. An apparatus for applying clips to tissue, comprising:

a clip chain formed of a plurality of clips connected to one another, each of the clips including a pair of opposed jaws biased toward an open configuration and a proximal end including a linking feature received between the jaws of an immediately proximal one the clips when the proximal one of the clips is in a closed configuration, the proximal one the clips, which receives the linking feature of the distal-most one of the clips between jaws thereof, having a first cross-sectional area larger than a second cross-sectional area of the distal-most one of the clips, which does not receive a linking feature between jaws thereof;

a control linkage extending between a distal end releasably coupled to a proximal-most one of the clips and a proximal end coupled to a control handle which, when the apparatus is in an operative position, remains accessible to a user to control a tension and compression applied to the clip chain via the control linkage; and

a magazine housing the clip chain and constraining the clips in the closed configuration, the magazine including a reduced cross-section portion at a distal end thereof smaller than the first cross-sectional are and larger than the second cross-sectional area to permit distal passage therethrough of only the distal-most one of the clips such that the jaws of the distal-most one of the clips revert to the open configuration to receive a target tissue therebetween.

2. The apparatus of claim 1 , wherein the magazine includes anti-pull back tabs which, when the distal-most one of the clips is drawn proximally into the magazine, engages a lock ring of the distal-most one of the clips to move the lock ring over the jaws of the distal-most one of the clips, locking the distal-most one of the clips in the closed configuration.

3. The apparatus of claim 1 , wherein opposing jaws of the clip include a snap and catch mechanism to lock the jaws in the closed configuration when the distal-most one of the clips is drawn proximally into the magazine.

4. The apparatus of claim 1 , wherein opposing jaws of the clip include corresponding snaps configured to engage one another and lock the jaws in the closed configuration when the distal-most one of the clips is drawn proximally into the magazine.

5. The apparatus of claim 1 , wherein the magazine includes a relief portion which permits the jaws of a clip immediately proximal of the distal-most one of the clips to open, releasing the linking feature of the distal-most one of the clips to separate the distal-most one of the clips from the clip chain.

6. The apparatus of claim 5 , wherein the relief portion includes one of a movable tab and an opening extending through the magazine.

7. The apparatus of claim 5 , wherein the clip includes a positioning feature formed along a portion thereof to interface with a portion of the magazine and position the clip immediately proximal of the distal-most one of the clips relative to the relief portion.

8. The apparatus of claim 1 , wherein the magazine is flexible for bending with respect to a longitudinal axis thereof.

9. The apparatus of claim 1 , wherein the magazine includes a plurality of partially circumferential slits formed thereon to increase a flexibility thereof.

10. A method for applying clips to tissue, comprising the steps of:

inserting a magazine housing a clip chain to a target area within a body, the clip chain including a plurality of clips connected to one another, each of the clips including a pair of opposed jaws biased toward an open configuration and a proximal end including a linking feature, the magazine constraining the clips in a closed configuration such that the linking feature of a distal-most one of the clips is received between the jaws of an immediately proximal one the clips;

applying a compression to the clip chain via a control linkage coupled to a proximal-most one of the clips in the clip chain by moving the clip chain distally relative to the magazine such that the distal-most one of the clips is pushed distally past a reduced cross-section portion at a distal end of the magazine such that the jaws thereof revert to the open configuration;

positioning the jaws of the distal-most magazine over a target tissue;

applying a tension to the clip chain via the control linkage by moving the clip chain proximally and drawing the distal-most one of the clips into the magazine to close the jaws of the distal-most one of the clips over the target tissue; and

moving the clip chain farther proximally to separate the distal-most one of the clips from the immediately proximal one of the clips.

11. The method of claim 10 , wherein drawing the distal-most one of the clips into the magazine locks the jaws in the closed configuration.

12. The method of claim 11 , wherein the distal-most one of the clips is locked in the closed configuration via an anti-pull tab of the magazine which engages a lock ring of the distal-most one of the clips to move the lock ring over the jaws of the distal-most one of the clips.

13. The method of claim 11 , wherein the distal-most one of the clips is locked in the closed configuration via a snap and catch mechanism formed on opposing jaws thereof.

14. The method of claim 11 , wherein the distal-most one of the clips is locked in the closed configuration via corresponding snaps formed on the opposing jaws to engage one another.

15. The method of claim 10 , wherein the distal-most one of the clip is separated from the immediately proximal one of the clips by positioning the immediately proximal one of the clips within a relief portion of the magazine which permits the jaws of the immediately proximal one of the clips to open and release the linking feature of the distal-most one of the clips.

16. The method of claim 15 , wherein the relief portion includes one of a movable tab and an opening extending through the magazine.

17. The method of claim 15 , wherein the immediately proximal one of the clips is positioned within the relief portion via a positioning feature formed along a portion of the clip which interface with a portion of the magazine to prevent the distal-most one of the clips from being moved any farther proximally.

18. The method of claim 10 , wherein the magazine is inserted to the target area through an endoscope.

19. The method of claim 10 , further comprising moving the magazine to a second target area within the body to deploy the immediately proximal one of the clips.

20. An apparatus for applying clips to tissue, comprising:

a magazine housing a clip chain formed of a plurality of clips connected to one another, each of the clips including clips including a pair of opposed jaws biased toward an open configuration and a proximal end including a linking feature, the magazine constraining the clips in a closed configuration such that the linking feature of a distal-most one of the clips is received within the between the jaws of an immediately proximal one the clips, the immediately proximal-most one of the clips, which receive the linking feature of the distal-most one of the clips between jaws thereof, having a first cross-sectional area larger than a second-cross sectional area of the distal-most clip, which does not receive a linking feature between jaws thereof, the magazine including a reduced cross-section portion at a distal end thereof which is smaller than the first cross-sectional area and larger than the second cross-sectional area to permit distal passage therethrough of only the distal-most one of the clips such that the jaws of the distal-most one of the clips revert to the open configuration to receive a target tissue therebetween; and

a control linkage extending between a distal end releasably coupled to a proximal-most one of the clips and a proximal end coupled to a control handle which, when the apparatus is in an operative position, remains accessible to a user to control a tension and compression applied to the clip chain via the control linkage.