Antimicrobial compositions containing cationic active ingredients and quaternary sugar derived surfactants
The antimicrobial composition of the present invention comprises a cationic active ingredient, a quaternized sugar-derived surfactant, and an optional foam boosting surfactant. The present antimicrobial compositions are free of the antimicrobial agent triclosan (i.e., 2,4,4′-trichloro-2′hydroxy-diphenylether), have a high cidal activity in a short amount of time, provide stable copious foam and exhibit enhanced tissue (e.g. skin) compatibility as defined by an in vitro whole toxicology assessment method.
1. An high foaming antimicrobial dermal cleanser comprising:
(a) between about 0.3 wt. % and about 5 wt. % of a quaternary ammonium containing compound;
(b) between about 0.05 wt. % and about 7.5 wt. % of a quaternized sugar-derived surfactant that is a polyquaternized alkyl polyglucoside of the formula
where n is an integer ranging from 4 to 6,
or a quaternized alkyl polyglucoside of the formula
where n is the degree of polymerization of 1-2, wherein R of the polyquaternized alkyl polyglucoside is an alkyl group having from about 6 to about 22 carbon atoms and wherein R 1 of the quaternized alkyl polyglucoside is an alkyl group having from about 6 to about 22 carbon atoms and R 2 of the quaternized alkyl polygluccoside is CH 3 (CH 2 ) x where x is an integer ranging from 0 to 21;
(c) between about 0.2 wt. % and about 6 wt. % of a foam boosting surfactant, comprising an alkyl amine oxide, alkyl ether amine oxide, or mixtures thereof; and
(d) between about 7.5 wt. % and about 99.3 wt. % of water;
wherein the relative weight ratio of quaternary ammonium containing compound to quaternized sugar derived surfactant to foam boosting surfactant is from about 1:0.2:0.2 to about 1:3:8;
wherein the composition does not contain anionic surfactants;
wherein the composition exhibits cidal activity;
wherein the composition is free of triclosan (2,4,4″-trichloro-2″-hydroxy-diphenylether).
2. The antimicrobial composition of claim 1 , wherein the quaternary ammonium containing compound is between about 0.5 wt. % and about 5 wt. % of the composition.
3. The antimicrobial composition of claim 1 , further comprising phospholipids, phospholipid, amphoteric surfactants, or mixtures thereof.
4. The antimicrobial composition of claim 1 , wherein the composition has a pH range from about 4.0 to about 9.0.
5. The antimicrobial composition of claim 1 , wherein the composition further comprises about 1 wt. % to about 25 wt. % adjuvants.
6. The antimicrobial composition of claim 1 , wherein the composition provides a log reduction in bacteria of greater than 5 in 30 seconds.
7. The antimicrobial composition of claim 1 , wherein the composition provides skin compatibility and skin health.