IP Library › Granted Patent US 9,096,853
Granted Patent B2
US 9,096,853 · App. 14/030,327 · Granted Aug 4, 2015

Modified siRNA molecules incorporating 5-fluoro-2′-deoxyuridine residues to enhance cytotoxicity

Inventors: John C. Schmitz, Sr. (Pittsburgh, PA); Edward Chu (Pittsburgh, PA); William H. Gmeiner (Yadkinville, NC)
Assignees: U.S. Department of Veterans Affairs; University of Pittsburgh-Of the Commonwealth System of Higher Education; Wake Forest University Health Sciences
C12N15/113C12N15/111C12N15/1137C12N2310/14C12N2310/344
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Quick Facts
Patent No.
US 9,096,853
App. No.
14/030,327
Granted
Aug 4, 2015
Kind
B2
Abstract

A synthesized siRNA molecule having the sense strand with one or more uridine bases replaced by one or more respective nucleoside analogs, such as 5-fluoro-2′-deoxyuridine (FdU).

Claims (4)

1. A nucleic acid comprising the nucleotide sequence of SEQ ID NO: 5, wherein position 4 of SEQ ID NO: 5 is a 5 -fluoro-2′-deoxyuridine (FdU) residue.

2. A nucleic acid comprising the nucleotide sequence of SEQ ID NO: 7, wherein position 21 of SEQ ID NO: 7 is a 5 -fluoro-2′-deoxyuridine (FdU) residue.

3. A nucleic acid comprising the nucleotide sequence of SEQ ID NO: 9, wherein positions 21-25 of SEQ ID NO: 9 are 5 -fluoro-2′-deoxyuridine (FdU) residues.

4. A nucleic acid comprising the nucleotide sequence of SEQ ID NO: 21, wherein positions 21-25 of SEQ ID NO: 21 are 5 -fluoro-2′-deoxyuridine (FdU) residues.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 29, 2015
From: GMEINER, WILLIAM H.
To: WAKE FOREST UNIVERSITY HEALTH SCIENCES, AN EDUCATIONAL INSTITUTION
Reel/Frame 035525/0466 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 27, 2015
From: SCHMITZ, JOHN C., SR.
To: U.S. DEPARTMENT OF VETERANS AFFAIRS; UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Reel/Frame 035499/0441 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 27, 2015
From: CHU, EDWARD
To: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Reel/Frame 035499/0519 →
Continuity (2)
Provisional Application 61704685 · Sep 24, 2012
Related Publication 20140088300A1 · Mar 27, 2014