Amide derivative and use thereof

1. An amide derivative of formula (I):

wherein:

R 1a , R 1b and R 1c each independently represent hydrogen atom, halogen atom, cyano group, hydroxy group, amino group, alkylamino group, optionally substituted alkyl group, or optionally substituted alkoxy group;

n represents an integer of 0 to 3;

m represents an integer of 0 to 3;

Het 1 represents thiazolyl group, isothiazolyl group, isoxazolyl group, thiadiazolyl group, oxadiazolyl group, furyl group, thienyl group, pyrrolyl group, pyrazolyl group, imidazolyl group, triazolyl group, pyridyl group, pyridazinyl group, pyrimidinyl group, pyrazinyl group, triazinyl group, cycloalkyl group, indolyl group, indazolyl group, benzimidazolyl group, benzisoxazolyl group, benzisothiazolyl group, benzoxazolyl group, benzothiazolyl group, quinolyl group, quinazolyl group, isoquinolyl group, quinoxalyl group, cinnolyl group, pyrrolopyrimidinyl group, pyrrolopyridyl group, imidazopyridyl group, or imidazopyrimidyl group;

Het 2 represents cycloalkyl group, aryl group, heterocycle group, or heteroaryl group;

R 2a , R 2b , R 3a , R 3b and R 3c each independently represent hydrogen atom, halogen atom, cyano group, hydroxy group, optionally substituted alkyl group, optionally substituted alkenyl group, optionally substituted alkynyl group, optionally substituted cycloalkyl group, optionally substituted heterocycle group, optionally substituted aryl group, optionally substituted heteroaryl group, —O—R 4a , —NR 4a R 4b , CO—R 4a , —CO—O—R 4a , —NHCO—R 4a , —SO—R 4a , —S—R 4a , —SO 2 —R 4a , —CONR 4a R 4b , —NH—CO—NR 4a R 4b , —NH—CO—O—R 4b , or —O—CO—NR 4a R 4b ;

R 4a and R 4b each independently represent hydrogen atom, alkyl group, alkoxyalkyl group, hydroxyalkyl group, haloalkyl group, aminoalkyl group, optionally substituted cycloalkyl group, optionally substituted aryl group, optionally substituted heterocycle group, or optionally substituted heteroaryl, or R 4a and R 4b are combined together to form an optionally substituted heterocycle group;

i represents an integer of 0 to 3;

k represents an integer of 0 to 2;

X represents N or C—R 5 ;

R 5 represents hydrogen atom, halogen atom, hydroxy group, cyano group, optionally substituted alkyl group, optionally substituted alkenyl group, optionally substituted alkynyl group, optionally substituted cycloalkyl group, optionally substituted aryl group, optionally substituted heterocycle group, optionally substituted heteroaryl group, —O—R 6a , —NR 6a R 6b , —CO—R 6a , —CO—O—R 6a , —N(R 6c )—CO—R 6a , —SO 2 —R 6a , —S—R 6a , —SO—R 6a , —CO—NR 6a R 6b , —N(R 6c )—CO—NR 6a R 6b , or —N(R 6c )—CO—O—R 6a ;

R 6a , R 6b and R 6c each independently represent hydrogen atom, alkyl group, haloalkyl group, aminoalkyl group, hydroxyalkyl group, alkenyl group, alkynyl group, optionally substituted cycloalkyl group, optionally substituted heterocycle group, optionally substituted cycloalkylalkyl group, or optionally substituted heterocyclic alkyl group, or R 6a and R 6b are combined together to form an optionally substituted heterocycle group;

Y and Z each independently represent N or C—R 7 ;

R 7 represents hydrogen atom, halogen atom, cyano group, optionally substituted alkyl group, or optionally substituted alkoxy group;

represents a single bond or a double bond;

A represents carbon atom or C—R 8 ;

R 8 represents hydrogen atom, halogen atom, hydroxy group, cyano group, optionally substituted alkyl group, optionally substituted alkenyl group, optionally substituted alkynyl group, optionally substituted cycloalkyl group, optionally substituted aryl group, optionally substituted heterocycle group, optionally substituted heteroaryl group, —O—R 9a , —NR 9a R 9b , —CO—R 9a , —CO—O—R 9a , —NR 9c —CO—R 9a , —SO 2 —R 9a , —S—R 9a , —SO—R 9a , —CO—NR 9a R 9b , —NR 9c —CO—NR 9a R 9b , or —NR 9c —CO—O—R 9a ;

R 9a , R 9b and R 9c each independently represent hydrogen atom, alkyl group, haloalkyl group, aminoalkyl group, hydroxyalkyl group, alkenyl group, alkynyl group, optionally substituted cycloalkyl group, optionally substituted heterocycle group, optionally substituted cycloalkylalkyl group or optionally substituted heterocyclic alkyl group, or R 9a and R 9b are combined together to form an optionally substituted heterocycle group;

D represents one of the following:

R 10 represents hydrogen atom, alkyl group, haloalkyl group, alkoxyalkyl group, hydroxyalkyl group, carboxyalkyl group, aminoalkyl group, -L 1a -R 13 , -L 1b -O—R 14 , -L 1b -O—CO—R 14 , -L 1b -O—Si(R 15 R 16 )—R 14 , -L 1a -SO 2 —R 14 , -L 1a -SO 2 —NR 14 R 15 , -L 1a -SO—R 14 , -L 1b -S—R 14 , -L 1b -NR 14 R 15 , -L 1b -N(R 16 )—CO—R 14 , -L 1a -CO—R 14 , -L 1a -CO—O—R 14 , -L 1a -CO—NR 14 R 15 , -L 1b -N(R 16 )—CO—O—R 14 , -L 1b -O—CO—NR 14 R 15 , or -L 1b -N(R 16 )—CO—NR 14 R 15 ;

R 13 represents optionally substituted cycloalkyl group, optionally substituted aryl group, optionally substituted heterocycle group, or optionally substituted heteroaryl group;

L 1a represents a bond, or —(CR A R B ) j —;

j represents an integer of 1-4;

R A and R B each independently represent hydrogen atom or alkyl group;

L 1b represents —(CR A R B ) j —, wherein j, R A and R B are defined as above;

R 14 , R 15 and R 16 each independently represent hydrogen atom, alkyl group, alkoxyalkyl group, hydroxyalkyl group, haloalkyl group, aminoalkyl group, optionally substituted cycloalkyl group, optionally substituted aryl group, optionally substituted heterocycle group, hydroxyalkyloxyalkyl group, haloalkyloxyalkyl group, carboxylalkyl group, alkyloxycarbonylalkyl group, alkylcarbonylalkyl group, alkylaminoalkyl group, amidealkyl group, alkylamidealkyl group, alkylcarbonylaminoalkyl group, alkylsulfonylalkyl group, alkylsulfoxyalkyl group, alkylsulfidealkyl group, optionally substituted cycloalkyloxyalkyl group, optionally substituted heterocyclic oxyalkyl group, optionally substituted cycloalkylalkoxyalkyl group, or optionally substituted heterocyclic alkoxyalkyl group, or R 14 and R 15 are combined together to form an optionally substituted heterocycle group; and

R 11 and R 12 each independently represent hydrogen atom, halogen atom, hydroxy group, alkyl group, haloalkyl group, alkoxyalkyl group, hydroxyalkyl group, carboxylalkyl group, aminoalkyl group, alkenyl group, -L 1a -R 13 , -L 1a -O—R 14 , -L 1a -O—CO—R 14 , -L 1a -O—Si(R 15 R 16 )—R 14 , L 1a -O—CO—NR 14 R 15 , -L 1a -CO—R 14 , -L 1a -CO—O—R 14 , -L 1a -CO—NR 14 R 15 , -L 1a -SO 2 —R 14 , -L 1a SO 2 —NR 14 R 15 , -L 1a -SO—R 14 , -L 1a -S—R 14 , -L 1a -NR 14 R 15 , -L 1a -N(R 16 )—CO—R 14 , -L 1a -N(R 16 )—CO—O—R 14 , or -L 1a -N(R 16 )—CO—NR 14 R 15 , or R 11 and R 12 are combined together to form an optionally substituted cycloalkyl group, or optionally substituted heterocycle group, or a pharmacologically acceptable salt thereof, wherein L 1a , L 1b , R 14 , R 13 , R 15 and R 16 are defined as above.

2. The amide derivative of claim 1 , wherein Het 1 represents thiazolyl group, furyl group, thienyl group, pyrrolyl group, pyrazolyl group, imidazolyl group, triazolyl group, pyridyl group, or indolyl group, or a pharmacologically acceptable salt thereof.

3. The amide derivative of claim 2 , wherein Y and Z represents C—R 7 , or a pharmacologically acceptable salt thereof.

4. The amide derivative of claim 3 , wherein X represents C—R 5 , or a pharmacologically acceptable salt thereof.

5. The amide derivative of claim 4 , wherein Het 2 represents aryl group or heteroaryl group, or a pharmacologically acceptable salt thereof.

6. The amide derivative of claim 5 , wherein:

represents a single bond; and

A represents C—R 8 ,

or a pharmacologically acceptable salt thereof.

7. The amide derivative of claim 5 , wherein

represents a double bond; and

A represents carbon atom,

or a pharmacologically acceptable salt thereof.

8. A compound selected from the group consisting of:

N-{6-[1-cyano-4-(morpholin-4-yl)cyclohexyl]pyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{6-[1-cyano-4-(morpholin-4-yl)cyclohexyl]pyridin-3-yl}-5-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carboxamide;

N-{6-[1-cyano-4-(methoxymethoxy)cyclohexyl]pyridin-3-yl}-5-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carboxamide;

5-methyl-N-{6-[4-(morpholin-4-yl)cyclohexyl]pyridin-3-yl}-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{6-[1-cyano-4-(morpholin-4-yl)cyclohexyl]pyridin-3-yl}-1-(3,5-dichloropyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxamide;

N-{6-[4-cyano-1-(2-methyltetrahydrofuran-3-yl)piperidin-4-yl]pyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{6-[4-cyano-1-(2-methyltetrahydrofuran-3-yl)piperidin-4-yl]pyridin-3-yl}-1-(5-cyclopropylpyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxamide;

N-{6-[4-cyano-1-(2-methyltetrahydrofuran-3-yl)piperidin-4-yl]pyridin-3-yl}-5-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-4-carboxamide;

N-{6-[1-cyano-4-(3-hydroxypyrrolidin-1-yl)cyclohexyl]pyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{6-[1-cyano-4-(morpholin-4-yl)cyclohexyl]pyridin-3-yl}-1-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]-5-methyl-1H-pyrazole-4-carboxamide;

N-{6-[1-cyano-4-methoxycyclohexyl]pyridin-3-yl}-5-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carboxamide;

5-methyl-N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{6-[1-cyano-4-(morpholin-4-yl)cyclohexyl]pyridin-3-yl}-1-(5-isopropylpyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxamide;

N-{6-[1-hydroxy-4-(morpholin-4-yl)cyclohexyl]pyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

1-(4-chlorophenyl)-N-[6-(1-cyano-4-hydroxycyclohexyl)pyridin-3-yl]-5-methyl-1H-pyrazole-4-carboxamide;

N-[6-(1-cyano-4-hydroxycyclohexyl)pyridin-3-yl]-1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxamide;

N-[6-(1-cyano-4-hydroxycyclohexyl)pyridin-3-yl]-5-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carboxamide;

1-(4-tert-butylphenyl)-N-[6-(4-hydroxycyclohexyl)pyridin-3-yl]-5-methyl-1H-pyrazole-4-carboxamide;

N-[6-(4-hydroxycyclohexyl)-5-methylpyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{6-[1-cyano-4-(2-hydroxyethoxyl)cyclohexyl]pyridin-3-yl}-5-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carboxamide;

N-[6-(8-cyano-1-oxaspiro[4.5]dec-8-yl)pyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-(6-{1-cyano-4-[N-(2,2-dimethylpropanoyl)-N-methylamino]cyclohexan-1-yl}pyridin-3-yl)-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{6-[1-cyano-4-(N-isobutyryl-N-methylamino)cyclohexan-1-yl]pyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{6-[1-cyano-4-(3-hydroxypyrrolidin-1-yl)cyclohex-1-yl]pyridin-3-yl}-5-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-4-carboxamide;

N-{6-[1-cyano-4-(morpholin-4-yl)cyclohexyl]pyridin-3-yl}-5-isopropyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-[6-(1-cyano-4-ethoxycyclohex-1-yl)pyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

1-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]-N-[6-(1-hydroxycyclohexan-4-yl)-5-methylpyridin-3-yl]-5-methyl-1H-pyrazole-4-carboxamide;

1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[6-(1-hydroxycyclohexan-4-yl)-5-methylpyridin-3-yl]-5-methyl-1H-pyrazole-4-carboxamide;

N-[6-(1-fluoro-4-hydroxycyclohexan-1-yl)pyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-[6-(4-hydroxycyclohexan-1-yl)pyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide; and

N-[6-(1-cyano-4-ethyl-4-hydroxycyclohexan-1-yl)pyridin-3-yl]-1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxamide, or a pharmacologically acceptable salt thereof.

9. A compound selected from the group consisting of:

N-{6-[r-1-cyano-c-4-(morpholin-4-yl)cyclohexyl]pyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{6-[r-1-cyano-c-4-(morpholin-4-yl)cyclohexyl]pyridin-3-yl}-5-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carboxamide;

N-{6-[r-1-cyano-c-4-(methoxymethoxy)cyclohexyl]pyridin-3-yl}-5-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carboxamide;

1-(5-cyclopropylpyridin-2-yl)-5-methyl-N-{6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1H-pyrazole-4-carboxamide;

trans-5-methyl-N-{6-[4-(morpholin-4-yl)cyclohexyl]pyridin-3-yl}-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{6-[r-1-cyano-c-4-(morpholin-4-yl)cyclohexyl]pyridin-3-yl}-1-(3,5-dichloropyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxamide;

cis-N-{ 6-[4-cyano-1-(2-methyltetrahydrofuran-3-yl)piperidin-4-yl]pyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{6-[4-cyano-1-(2-hydroxy-2-methylpropyl)piperidin-4-yl]pyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

cis-N-{ 6-[4-cyano-1-(2-methyltetrahydrofuran-3-yl)piperidin-4-yl]pyridin-3-yl}-1-(5-cyclopropylpyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxamide;

cis-N-{6-[4-cyano-1-(2-methyltetrahydrofuran-3-yl)piperidin-4-yl]pyridin-3-yl}-5-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-4-carboxamide;

N-{6-[4-cyano-1-(2-hydroxy-2-methylpropyl)piperidin-4-yl]pyridin-3-yl}-1-(5-cyclopropylpyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxamide;

N-{6-[r-1-cyano-c-4-(3-hydroxypyrrolidin-1-yl)cyclohexyl]pyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{6-[r-1-cyano-c-4-(morpholin-4-yl)cyclohexyl]pyridin-3-yl}-1-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]-5-methyl-1H-pyrazole-4-carboxamide;

N-{6-[r-1-cyano-c-4-methoxycyclohexyl]pyridin-3-yl}-5-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carboxamide;

1-[5-chloro-3-fluoropyridin-2-yl]-5-methyl-N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1H-pyrazole-4-carboxamide;

5-methyl-N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

(R)-5-methyl-N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

(S)-5-methyl-N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-[6-(4-hydroxycyclohex-1-en-1-yl)-5-methyl-pyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

1-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]-5-methyl-N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1H-pyrazole-4-carboxamide;

1-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]-5-methyl-N-[5-methyl-6-(4-hydroxycyclohex-1-en-1-yl)pyridin-3-yl]-1H-pyrazole-4-carboxamide;

N-{6-[r-1-cyano-c-4-(morpholin-4-yl)cyclohexyl]pyridin-3-yl}-1-(5-isopropylpyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxamide;

5-methyl-N-{6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{6-[r-1-hydroxy-e-4-(morpholin-4-yl)cyclohexyl]pyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-[6-(1-cyano-4-oxocyclohexyl)pyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

1-(4-chlorophenyl)-N-[6-(r-1-cyano-c-4-hydroxycyclohexyl)pyridin-3-yl]-5-methyl-1H-pyrazole-4-carboxamide;

N-[6-(r-1-cyano-c-4-hydroxycyclohexyl)pyridin-3-yl]-1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxamide;

N-[6-(r-1-cyano-c-4-hydroxycyclohexyl)pyridin-3-yl]-5-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carboxamide;

trans-1-(4-tert-butylphenyl)-N-[6-(4-hydroxycyclohexyl)pyridin-3-yl]-5-methyl-1H-pyrazole-4-carboxamide;

N-[6-(4-hydroxycyclohex-1-en-1-yl)-5-methylpyridin-3-yl]-5-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-4-carboxamide;

trans-N-[6-(4-hydroxycyclohexyl)-5-methylpyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{6-[r-1-cyano-c-4-(2-hydroxyethoxyl)cyclohexyl]pyridin-3-yl}-5-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carboxamide;

N-[6-(3,6-dihydro-2H-pyran-4-yl)-5-methylpyridin-3-yl]-5-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-4-carboxamide;

N-{6-[4-(N-isobutyryl-N-methylamino)cyclohex-1-en-1-yl]-5-methylpyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-(6-{4-[N-(2,2-dimethylpropion-1-yl)-N-methylamino]cyclohex-1-en-1-yl}-5-methylpyridin-3-yl)-5-methyl-1-(pyridin-2-yl)-1H-pyrazole-4-carboxamide;

1-(4-fluorophenyl)-N-{6-[4-(N-isobutyryl-N-methylamino)cyclohex-1-en-1-yl]-5-methylpyridin-3-yl}-5-methyl-1H-pyrazole-4-carboxamide;

N-[6-(4-N,N-dimethylcarbamoylcyclohex-1-en-1-yl)-5-methylpyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

1-(5-cyclopropylpyridin-2-yl)-N-[6-(4-N,N-dimethylcarbamoylcyclohex-1-en-1-yl)-5-methylpyridin-3-yl]-5-methyl-1H-pyrazole-4-carboxamide;

3-methyl-N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-2-[4-(trifluoromethyl)phenyl]-3H-imidazole-4-carboxamide;

N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-2-[4-(trifluoromethyl)phenyl]thiazole-4-carboxamide;

5-methyl-N-(5-methyl-6-{4-[N-methyl-N-(2,2,2-trifluoroacetyl)amino]cyclohex-1-en-1-yl}pyridin-3-yl)-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-[6-(c-8-cyano-r-1-oxaspiro[4.5]dec-8-yl)pyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-(6-{r-1-cyano-c-4-[N-(2,2-dimethylpropanoyl)-N-methylamino]cyclohexan-1-yl}pyridin-3-yl)-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{6-[r-1-cyano-c-4-(N-isobutyryl-N-methylamino)cyclohexan-1-yl]pyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

5-methyl-N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1-[4-methyl-5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{6-[r-1-cyano-c-4-(3-hydroxypyrrolidin-1-yl)cyclohex-1-yl]pyridin-3-yl}-5-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-4-carboxamide;

N-{6-[r-1-cyano-c-4-(morpholin-4-yl)cyclohexyl]pyridin-3-yl}-5-isopropyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

5-isopropyl-N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

5-methyl-N-{5-methyl-6-[4-(3-oxomorpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-[6-(r-1-cyano-c-4-ethoxycyclohex-1-yl)pyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

1-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]-5-methyl-N-[5-methyl-6-(4-oxocyclohex-1-yl)pyridin-3-yl]-1H-pyrazole-4-carboxamide;

1-[3-chloro-5-(trifluoromethyl) pyri din-2-yl]-5-methyl-N-[5-methyl-6-(4-oxocyclohex-1-yl)pyridin-3-yl]-1H-pyrazole-4-carboxamide;

N-[6-(1-fluoro-4-oxocyclohexan-1-yl)pyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

trans-1-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]-N-[6-(1-hydroxycyclohexan-4-yl)-5-methylpyridin-3-yl]-5-methyl-1H-pyrazole-4-carboxamide;

trans-1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[6-(1-hydroxycyclohexan-4-yl)-5-methylpyridin-3-yl]-5-methyl-1H-pyrazole-4-carboxamide;

N-[6-(c-1-fluoro-r-4-hydroxycyclohexan-1-yl)pyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

trans-N-[6-(4-hydroxycyclohexan-1-yl)pyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-(6-{4-[N-(2,2-dimethylpropion-1-yl)-N-methylamino]cyclohex-1-en-1-yl}-5-methylpyridin-3-yl)-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{6-[4-(1-hydroxy-1-methylethyl)cyclohex-1-en-1-yl]-5-methylpyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-[6-(r-1-cyano-4-ethyl-c-4-hydroxycyclohexan-1-yl)pyridin-3-yl]-1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxamide;

5-methyl-N-{5-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyrazin-2-yl}-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{5-cyano-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{6-[1-(2,2-dimethylpropanoyl)-1,2,3,6-tetrahydropyridin-4-yl]-5-methylpyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

5-methyl-N-{5-methyl-6-[1-(propane-2-sulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

5-methyl-N-[5-methyl-6-(1,2,3,6-tetrahydro-1-trifluoroacetylpyridin-4-yl)pyridin-3-yl]-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{6-[4-cyano-1-(propane-2-sulfonyl)piperidin-4-yl]pyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

5-methyl-N-{5-methyl-1-(pyrrolidin-1-ylcarbonyl)-6-[1,2,3,6-tetrahydropyridin-4-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

5-methyl-N-{5-methyl-6-[1-(propane-2-sulfonyl)piperidin-4-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{6-[4-cyano-1-(cyclopropanesulfonyl)piperidin-4-yl]pyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{6-[4-cyano-1-(dimethylsulfamoyl)piperidin-4-yl]pyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

5-methyl-N-{5-methyl-6-[1-(trifluoroacetyl)piperidin-4-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-[6-(4-cyano-1-trifluoromethanesulfonylpiperidin-4-yl)pyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-(5-{4-[N-(2,2-dimethylpropion-1-yl)-N-methylamino]cyclohex-1-en-1-yl}pyrazin-2-yl)-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-(6-{4-[N-(2,2-dimethylpropion-1-yl)-N-methylamino]cyclohex-1-en-1-yl}-5-methoxypyridin-3-yl)-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{5-methoxy-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-(6-{4-[N-(2,2-dimethylpropion-1-yl)-N-methylamino]cyclohex-1-en-1-yl}-5-(trifluoromethyl)pyridin-3-yl)-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

N-{6-[1-(dimethylsulfamoyl)piperidin-4-yl]-5-methylpyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide;

5-methyl-N-{6-[1-(propane-2-sulfonyl)piperidin-4-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide; and

5-methyl-N-{6-[1-(trifluoromethanesulfonyl)piperidin-4-yl]pyridin-3-yl}-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide, or a pharmacologically acceptable salt thereof.

10. A method for inhibiting IL-17 production, comprising:

administering an effective amount of the amide derivative of claim 1 or a pharmacologically acceptable salt thereof to a patient in need thereof.

11. A method for treating multiple sclerosis, systemic lupus erythematosus, psoriasis, inflammatory bowel disease, or asthma, comprising:

administering an effective amount of the amide derivative of claim 1 or a pharmacologically acceptable salt thereof to a patient in need thereof.

12. A method for treating rheumatoid arthritis, comprising:

administering an effective amount of the amide derivative of claim 1 or a pharmacologically acceptable salt thereof to a patient in need thereof.