Chemical compositions for enhancing transdermal delivery of therapeutic agents
The present application discloses chemical compositions and methods for enhancing the transdermal permeation of therapeutic agents through skin. The chemical compositions and methods of the invention can include combinations of a first fatty acid having about 14 or more carbon atoms and a second fatty acid having about 10 or less carbon atoms. These compositions are useful for the delivery of therapeutic agents, in particular hard to deliver drugs such as those that have fused rings, including ondansetron, and large drugs such as peptides. The compositions of the invention can be formulated as transdermal gels, lotions, creams, transdermal patches, sprays or mists.
1. A composition for use on human skin comprising:
a mixture comprising
ondansetron, an ondansetron salt, or a mixture thereof;
from about 1% to about 5% by weight of the composition of oleic acid; and
from about 1% to about 5% by weight of the composition of levulinic acid.
2. The composition of claim 1 , comprising ondansetron.
3. The composition of claim 1 , comprising an ondansetron salt.
4. The composition of claim 3 , wherein the ondansetron salt is ondanstron hydrochloride.
5. The composition of claim 1 , comprising oleic acid.
6. The composition of claim 1 comprising ondansetron and an ondansetron salt.
7. A transdermal patch for use on human skin comprising
a mixture comprising
ondansetron, an ondansetron salt, or a mixture thereof;
from about 1% to about 5% by weight of the mixture of oleic acid; and
from about 1% to about 5% by weight of the mixture of levulinic acid.
8. The transdermal patch of claim 7 , comprising ondansetron.
9. The transdermal patch of claim 7 , comprising an ondansetron salt.
10. The transdermal patch of claim 9 , wherein the ondansetron salt is ondanstron hydrochloride.
11. The transdermal patch of claim 7 comprising ondansetron and an ondansetron salt.