Anti-cancer adenoviruses
Anti-cancer adenoviruses, methods of use and methods of making the same are provided herein.
1. A method of treating a cancer with reduced expression or activity of p53, comprising administering an effective amount of a recombinant adenovirus that is E1B-55k impaired and E4-ORF3 impaired to a subject in need thereof, wherein the recombinant adenovirus is not replication impaired in a p53 impaired cell.
2. The method of claim 1 , wherein the cancer is lung cancer, skin cancer or breast cancer.
3. The method of claim 1 , wherein the cancer to be treated is pre-malignant breast cancer.
4. The method of claim 1 , wherein the recombinant adenovirus expresses a mutated E4-ORF3 product.
5. The method of claim 1 , wherein the recombinant adenovirus comprises an E4-ORF3 gene that is wholly or partially deleted.
6. The method of claim 1 , wherein the recombinant adenovirus expresses a mutated E1B-55k gene product.
7. The method of claim 1 , wherein the recombinant adenovirus comprises an E1B-55k gene that is wholly or partially deleted.
8. The method of claim 1 , wherein the recombinant adenovirus comprises an E4-ORF3 gene that is wholly or partially deleted and an E1B-55k gene that is wholly or partially deleted.
9. The method of claim 1 , wherein the recombinant adenovirus comprises a mutated E4-ORF3 gene and an E1B-55k gene that is wholly or partially deleted.