Zeaxanthin formulations with additional ocular-active nutrients, for protecting eye health and treating eye disorders
Oral formulations for promoting eye health, and in particular for preventing or treating macular degeneration, are disclosed, containing zeaxanthin, a carotenoid pigment, and at least two or more additional ocular-active nutrients selected from lipoic acid, omega-3 fatty acids, plant-derived compounds such as flavonoids, anthocyanins, or polyphenolics, taurine, carnitine, Coenzyme-Q10, carnosine, and nutrients that stimulate the production of glutathione. Processes are disclosed for identifying ocular-active nutrients that will interact in a synergistic and potentiating manner with zeaxanthin, to provide better and more effective protection, for eye health, than can be provided by zeaxanthin alone. Additional optional agents include zinc, vitamin E, and vitamin C.
1. A nutrient formulation in a unit dosage or daily dosage form for oral ingestion, wherein a recommended daily dosage of said nutrient formulation comprises:
a. at least 3 milligrams of zeaxanthin, which is present in 3R-3′R stereoisomer form and is substantially free of meso-zeaxanthin stereoisomers;
b. zinc at a dosage that (i) does not exceed 40 milligrams of elemental zinc and (ii) does not require a copper additive to the formulation to inhibit zinc-induced anemia;
c. vitamin C;
d. at least one tocopherol with anti-oxidant activity; and
wherein the nutrient formulation is provided in the form selected from the group consisting of capsules, tablets, liquids, and powders for oral ingestion.
2. The nutrient formulation of claim 1 , wherein said nutrient formulation is present in a form that provides sustained release over a span of at least 3 hours following ingestion.
3. The nutrient formulation of claim 1 , wherein said formulation also comprises at least one agent that has been added to increase digestive uptake of lipophilic compounds.
4. The nutrient formulation of claim 1 , wherein the formulation is in the form of capsules containing oily carrier materials.
5. The nutrient formulation of claim 1 , wherein the vitamin C is in the form of absorbic acid.
6. The nutrient formulation of claim 1 , further comprising lipoic acid and omega-3 fatty acids.
7. The nutrient formulation of claim 1 , wherein the daily dosage of zeaxanthin is at least 10 milligrams.
8. The nutrient formulation of claim 1 , wherein the formulation is in the form of a capsule, and a plurality of capsules are required to achieve the at least 3 milligram daily dosage of zeaxanthin.