Transdermal compositions of ibuprofen and methods of use thereof
A transdermal composition comprising ibuprofen or salts thereof and a gelling agent which can be used for the treatment of such disorders as pain, inflammation, arthritis, muscle spasm and associated symptoms in humans and animals.
1. A composition for transdermal administration of ibuprofen comprising:
S(+)-ibuprofen in an amount of about 5% by weight of the composition;
a gelling agent;
isopropyl alcohol;
isopropyl myristate;
water; and
propylene glycol in an amount between about 20% and about 60% by weight of the composition;
wherein the composition has an apparent pH of 7.0.
2. The composition of claim 1 , wherein the gelling agent comprises hydroxypropyl cellulose.
3. The composition of claim 1 , wherein the gelling agent is in an amount between about 0.1% and about 10% by weight of the composition.
4. The composition of claim 1 , wherein the gelling agent is in an amount between about 1% and about 5% by weight of the composition.
5. The composition of claim 1 , wherein the isopropyl alcohol is in an amount between about 25% and about 70% by weight of the composition.
6. The composition of claim 1 , wherein the isopropyl alcohol is in an amount between about 35% and about 40% by weight of the composition.
7. The composition of claim 1 , wherein the composition further comprises oleic acid.
8. The composition of claim 1 , wherein the isopropyl myristate is in an amount between about 0.1% and about 25% by weight of the composition.
9. The composition of claim 1 , wherein the isopropyl myristate is in an amount between about 1% and about 5% by weight of the composition.
10. The composition of claim 1 , wherein the viscosity of the composition is between about 5,000 and about 100,000 cps.
11. The composition of claim 1 , wherein the viscosity of the composition is between about 10,000 cps and about 50,000 cps.
12. The composition of claim 1 , wherein the viscosity of the composition is between about 15,000 cps and about 35,000 cps.
13. A method of reducing pain or inflammation, the method comprising administering to a dermal surface of a subject in need of a reduction in pain or inflammation the composition of claim 1 .
14. The method of claim 13 , wherein the dermal surface is on the subject's neck.
15. The method of claim 13 , wherein the dermal surface is on the subject's back.
16. The method of claim 13 , wherein the dermal surface is on an arm of the subject.
17. The method of claim 13 , wherein the dermal surface is on a hand of the subject.
18. The method of claim 13 , wherein the dermal surface is on a foot of the subject.
19. The method of claim 13 , wherein the dermal surface is on a leg of the subject.
20. The method of claim 13 , wherein the dermal surface is on a joint of the subject.
21. A composition for transdermal administration of ibuprofen comprising:
S(+)-ibuprofen in an amount of about 5% by weight of the composition;
a gelling agent in an amount of about 1.5% to about 3% by weight of the composition;
water in an amount of about 15% to about 30% by weight of the composition;
propylene glycol in an amount of about 5% to about 25% by weight of the composition;
isopropyl myristate; and
isopropyl alcohol in an amount that is about 25% to about 70% by weight of the composition, and is greater than the weight percent of water in the composition,
wherein the composition has an apparent pH of 7.0.
22. The composition of claim 21 , wherein the weight percent of water in the composition is about 30%.
23. The composition of claim 21 , wherein the gelling agent comprises hydroxypropyl cellulose.
24. The composition of claim 21 , wherein the weight percent of the propylene glycol in the composition is 20%.
25. The composition of claim 21 , wherein the weight percent of the propylene glycol in the composition is 10%.
26. The composition of claim 21 , wherein the isopropyl myristate is present in an amount that is about 1% to about 5% by weight of the composition.
27. The composition of claim 21 , wherein
the weight percent of water in the composition is about 30%;
the gelling agent comprises hydroxypropyl cellulose; and
the isopropyl myristate is present in an amount that is about 1% to about 5% by weight of the composition.
28. The composition of claim 27 , wherein the weight percent of the propylene glycol in the composition is 20%.
29. The composition of claim 27 , wherein the weight percent of the propylene glycol in the composition is 10%.
30. The composition of claim 1 , wherein the gelling agent comprises a polymer selected from the group consisting of methyl cellulose, ethyl cellulose, hydroxycellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, and mixtures thereof.
31. The composition of claim 21 , wherein the gelling agent comprises a polymer selected from the group consisting of methyl cellulose, ethyl cellulose, hydroxycellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, and mixtures thereof.
32. The composition of claim 1 , wherein the gelling agent comprises an acrylic acid polymer.
33. The composition of claim 21 , wherein the gelling agent comprises an acrylic acid polymer.
34. The composition of claim 1 , wherein the gelling agent is a polymer other than an acrylic acid polymer.
35. The composition of claim 21 , wherein the gelling agent is a polymer other than an acrylic acid polymer.