Medical device for dispersing medicaments
For selective treatment of diseased tissue sections or organ parts, the surface of medical devices entering into contact with areas thereof under pressure is coated with lipophilic substantially water-insoluble medicaments binding to various tissue components with good adherence thereto, said medicaments having an effect thereupon a short time after entering into contact therewith without exerting a harmful influence upon adjacent healthy tissue.
1. A medical device comprising a balloon having a surface;
wherein the balloon surface comprises paclitaxel and a low molecular weight matrix substance; and
wherein the low molecular weight matrix substance comprises a hydrophilic material.
2. The medical device of claim 1 wherein the hydrophilic material comprises a sugar alcohol.
3. The medical device of claim 1 wherein said medical device further comprises a stent.
4. The medical device of claim 1 wherein the balloon is a folded balloon.
5. The medical device of claim 1 wherein the paclitaxel and matrix substance are present as a dry solid on the balloon surface.
6. The medical device of claim 1 wherein the concentration of paclitaxel on said surface is up to 5 μg/mm 2 .
7. The medical device of claim 1 wherein the low molecular weight matrix substance has a molecular weight of less than 5000 D.
8. The medical device of claim 7 wherein the low molecular weight matrix substance has a molecular weight of less than 2000 D.
9. A medical device comprising a balloon having a surface;
wherein the balloon surface comprises paclitaxel and a low molecular weight matrix substance adhered to the balloon surface; and
wherein the low molecular weight matrix substance comprises sugars, sugar alcohols, low molecular weight polyethylene glycols, biocompatible organic salts, or biocompatible inorganic salts.
10. The medical device of claim 9 wherein the low molecular weight matrix substance comprises a sugar alcohol.
11. The medical device of claim 9 wherein said medical device further comprises a stent.
12. The medical device of claim 9 wherein the balloon is a folded balloon.
13. The medical device of claim 9 wherein the balloon surface consists of a material to which the paclitaxel and matrix substance adhere sufficiently well to resist forces required for folding, essentially without damage.
14. The medical device of claim 9 wherein the concentration of paclitaxel on said surface is up to 5 μg/mm 2 .
15. The medical device of claim 9 wherein the low molecular weight matrix substance has a molecular weight of less than 5000 D.
16. The medical device of claim 15 wherein the low molecular weight matrix substance has a molecular weight of less than 2000 D.
17. A medical device comprising a balloon having a surface;
wherein the balloon surface comprises paclitaxel and a low molecular weight inert matrix substance; and
wherein the low molecular weight inert matrix substance comprises a hydrophilic material.
18. The medical device of claim 17 wherein the hydrophilic material comprises a sugar alcohol.
19. The medical device of claim 17 wherein said medical device further comprises a stent.
20. The medical device of claim 17 wherein the balloon is a folded balloon.
21. The medical device of claim 17 wherein the paclitaxel and matrix substance are present as a dry solid on the balloon surface.
22. The medical device of claim 17 wherein the concentration of paclitaxel on said surface is up to 5 μg/mm 2 .
23. The medical device of claim 17 wherein the low molecular weight inert matrix substance has a molecular weight of less than 5000 D.
24. A medical device comprising a balloon having a surface;
wherein the balloon surface comprises paclitaxel and a low molecular weight inert matrix substance adhered to the balloon surface; and
wherein the low molecular weight inert matrix substance comprises sugars, sugar alcohols, low molecular weight polyethylene glycols, biocompatible organic salts, or biocompatible inorganic salts.
25. The medical device of claim 24 wherein the low molecular weight matrix substance comprises a sugar alcohol.
26. The medical device of claim 24 wherein said medical device further comprises a stent.
27. The medical device of claim 24 wherein the balloon is a folded balloon.
28. The medical device of claim 24 wherein the balloon surface consists of a material to which the paclitaxel and inert matrix substance adhere sufficiently well to resist forces required for folding, essentially without damage.
29. The medical device of claim 24 wherein the low molecular weight inert matrix substance has a molecular weight of less than 5000 D.
30. The medical device of claim 29 wherein the low molecular weight inert matrix substance has a molecular weight of less than 2000 D.