Shapeable bone graft substitute and instruments for delivery thereof
Injectable bone graft material having a biocompatible, resorbable polymer and a biocompatible, resorbable inorganic material exhibiting macro, meso, and microporosities.
1. A bone graft delivery system comprising:
a syringe containing a dry bone graft material comprising a homogeneous composite comprising collagen and calcium phosphate, wherein about 15% to about 30% by weight of the dry bone graft material is collagen, wherein the dry bone graft material has macroporosity, mesoporosity and microporosity, and has pore volume of at least about 50%; and
a delivery tube,
wherein said dry bone graft material is constructed such that the dry bone graft material becomes a flowable body when wetted with a fluid, and
wherein homogeneous means that the porosity and pore size distribution is the same throughout the composite.
2. The bone graft delivery system of claim 1 further comprising a plunger that mates with the delivery tube.
3. The bone graft delivery system of claim 1 wherein the flowable body is at least 75% porous.
4. The bone graft delivery system of claim 1 wherein the flowable body is at least 80% porous.
5. The bone graft delivery system of claim 1 wherein the flowable body is at least 90% porous.
6. The bone graft delivery system of claim 1 wherein the biocompatible polymer is collagen.
7. The bone graft delivery system of claim 1 wherein about 15% to about 25% by weight of the flowable body, comprises the biocompatible polymer.
8. The bone graft delivery system of claim 1 wherein about 15% to about 20% by weight of the flowable body, comprises the biocompatible polymer.
9. The bone graft delivery system of claim 1 wherein about 20% to about 30% by weight of the flowable body, comprises the biocompatible polymer.
10. The bone graft delivery system of claim 1 wherein the calcium phosphate comprises calcium phosphate morsels in a size range of about 250 μm to about 2000 μm.
11. The bone graft delivery system of claim 1 wherein the calcium phosphate comprises calcium phosphate morsels in a size range of about 250 μm to about 1000 μm.
12. The bone graft delivery system of claim 1 wherein said calcium phosphate comprises calcium phosphate morsels in a size range of about 100 μm to about 4000 μm.
13. The bone graft delivery system of claim 1 wherein the dry bone graft material is cylindrical-, block-, strip-, sheet- or wedge-shaped.