Method and apparatus for acne treatment using low intensity light therapy
Disclosed is a system and method for treatment of skin disorders. More particularly, the disclosed invention is directed toward the reduction of acne and acne related bacteria using low-intensity light therapy. In an illustrative embodiment, skin containing acne bacteria is treated with a series of pulses of light from a light emitting diode. The LED has a dominant emissive wavelength of about 660 nm and an energy output of about 4 m W. The acne bacteria-containing tissue is exposed to pulses from the light source about 100 times for about 250 milliseconds per pulse, with an interpulse interval of about 100 milliseconds.
1. A method, comprising:
exposing tissue containing acne bacteria to at least one source of narrowband, multichromatic electromagnetic radiation having at least one dominant emissive wavelength of from about 300 nm to about 1400 nm, wherein the dominant emissive wavelength approximately corresponds with an absorption maxima of the tissue;
operating the at least one source of narrowband, multichromatic electromagnetic radiation at a power output of about 20 mW or lower and at an energy fluence in the range of about 0.01 J/cm 2 to about 4 J/cm 2 ; and
observing a reduction in acne bacteria present on or in the tissue,
wherein the narrowband, multichromatic electromagnetic radiation has a bandwidth less than or equal to about +/ 100 nm around the at least one dominant emissive wavelength.
2. The method of claim 1 wherein the acne bacteria is present in or on the tissue and the tissue is selected from the group consisting of sebaceous oil glands, sebaceous ducts, sebocytes, supporting tissue thereof, and combinations thereof.
3. The method of claim 1 wherein the narrowband, multichromatic electromagnetic radiation has a dominant emissive wavelength of from about 390 nm to about 1400 nm.
4. The method of claim 3 wherein the dominant emissive wavelength is selected from the group consisting of 400 nm, 420 nm, 430 nm, 445 nm, 475 nm, 590 nm, 635 nm, 655 nm, 660 nm, 670 nm, 780 nm, 785 nm, 810 nm, 830 nm, 840 nm, 860 nm, 904 nm, 915 nm, 980 nm, 1015 nm, 1060 nm, 1260 nm, and 1400 nm.
5. The method of claim 1 comprising applying a photomodulation enhancing agent to the tissue containing or surrounding the acne bacteria prior to exposing said tissue to said source of narrowband, multichromatic electromagnetic radiation.
6. The method of claim 5 wherein said photomodulation enhancing agent comprises a composition having an active agent selected from the group consisting of at least one of Vitamin C, Vitamin E, Vitamin A, Vitamin K, Vitamin F, Retin A (Tretinoin), Adapalene, Retinol, Hydroquinone, Kojic acid, a growth factor, echinacea, anantibiotic, an antifungal, an antiviral, a bleaching agent, an alpha hydroxy acid, a beta hydroxy acid, salicylic acid, antioxidant triad compound, a seaweed derivative, a salt water derivative, an antioxidant, a phytoanthocyanin, epigallocatechin 3-ganate, a phytonutrient, a botanical product, a herbaceous product, a hormone, an enzyme, a mineral, a genetically engineered substance, a cofactor, a catalyst, an antiaging substance, insulin, trace elements (including ionic calcium, magnesium, etc), minerals, Rogaine, a hair growth stimulating substance, a hair growth inhibiting substance, a dye, a natural or synthetic melanin, a metalloproteinase inhibitor, proline, hydroxyproline, an anesthetic substance, chlorophyll, copper chlorophyllin, chloroplasts, carotenoids, bacteriochlorophyll, phycobilins, carotene, xanthophyll, anthocyanin, and derivatives, subcomponents, and analogs of the above, both natural and synthetic, and mixtures thereof.
7. The method of claim 6 wherein the photomodulation enhancing agent is selected from the group consisting of chlorophyll, carotenoids, bacteriochlorophyll, phycobilins, porphyrins, derivatives thereof, and mixtures thereof.
8. The method of claim 5 further comprising subjecting the tissue to a penetration enhancing procedure after applying said photomodulation enhancing agent thereto and prior to exposing said tissue to said source of electromagnetic radiation.
9. The method of claim 8 wherein the penetration enhancing procedure comprises a procedure selected from the group consisting of enzyme peel, microdermabrasion, solvent stripping, tape stripping, scrubbing, laser ablation, laser vaporization, chemical peeling, electrical stimulation, laser treatments using high peak power and short pulse durations, ultrasound, and combinations thereof.
10. The method of claim 8 wherein the penetration enhancing procedure comprises microdermabrasion.
11. The method of claim 8 wherein the penetration enhancing procedure comprises exposing said photomodulation enhancing agent to ultrasound.
12. The method of claim 3 wherein the source of narrowband, multichromatic electromagnetic radiation is a light emitting diode.
13. The method of claim 12 wherein the energy output of the light emitting diode is from about 0.5 mW to about 20 mW.
14. The method of claim 13 wherein the energy output of the light emitting diode is about 4 mW.
15. The method of claim 14 wherein the light emitting diode has a dominant wavelength selected from the group consisting of 400 nm, 420 nm, 430 nm, 445 nm, 475 nm, 590 nm, 635 nm, 655 nm, 660 nm, 670 nm, 780 nm, 785 nm, 810 nm, 830 nm, 840 nm, 860 nm, 904 nm, 915 nm, 980 nm, 1015 nm, 1060 nm, 1260 nm, and 1400 nm.
16. A method, comprising:
exposing acne bacteria to at least one source of narrowband, multichromatic electromagnetic radiation having a power output of from about 0.5 mW to about 20 mW, wherein the narrowband, multichromatic electromagnetic radiation has at least one dominant emissive wavelength between about 300 nm and about 1400 nm, which approximately corresponds with an absorption maxima of the tissue, and wherein the exposure is continuous for a duration of from about 0.5 minutes to about 60 minutes, wherein the narrowband, multichromatic electromagnetic radiation has a bandwidth less than or equal to about +/ 100 nm around the at least one dominant emissive wavelength.
17. The method of claim 16 wherein the tissue is continuously exposed to the source of narrowband, multichromatic electromagnetic radiation for a duration of about 15 minutes.
18. The method of claim 16 wherein the energy output of the source of narrowband, multichromatic electromagnetic radiation is about 4 mW.
19. The method of claim 16 comprising applying a photomodulation enhancing agent to the tissue containing or surrounding the acne bacteria prior to exposing said tissue to said source of narrowband, multichromatic electromagnetic radiation.
20. The method of claim 19 wherein said photomodulation enhancing agent comprises a composition have an active agent selected from the group consisting of at least one of Vitamin C, Vitamin E, Vitamin A, Vitamin K, Vitamin F, Retin A (Tretinoin), Adapalene, Retinol, Hydroquinone, Kojic acid, a growth factor, echinacea, an antibiotic, an antifungal, an antiviral, a bleaching agent, an alpha hydroxy acid, a beta hydroxy acid, salicylic acid, antioxidant triad compound, a seaweed derivative, a salt water derivative, an antioxidant, a phytoanthocyanin, epigallocatechin-3-ganate, a phytonutrient, a botanical product, a herbaceous product, a hormone, an enzyme, a mineral, a genetically engineered substance, a cofactor, a catalyst, an antiaging substance, insulin, trace elements (including ionic calcium, magnesium, etc), minerals, Rogaine, a hair growth stimulating substance, a hair growth inhibiting substance, a dye, a natural or synthetic melanin, a metalloproteinase inhibitor, proline, hydroxyproline, an anesthetic substance, chlorophyll, copper chiorophyllin, chloroplasts, carotenoids, bacteriochlorophyll, phycobilins, carotene, xanthophyll, anthocyanin, and derivatives, subcomponents, and analogs of the above, both natural and synthetic, and mixtures thereof.
21. The method of claim 19 wherein the photo modulation enhancing agent is selected from the group consisting of chlorophyll, carotenoids, bacteriochlorophyll, phylocibins, porphyrins, derivatives thereof, and mixtures thereof.
22. The method of claim 19 further comprising subjecting the tissue to a penetration enhancing procedure after applying said photomodulation enhancing agent thereto and prior to exposing said tissue to said source of electromagnetic radiation.
23. The method of claim 22 wherein the penetration enhancing procedure comprises a procedure selected from the group consisting of enzyme peel, microderm abrasion, solvent stripping, tape stripping, scrubbing, laser ablation, laser vaporization, chemical peeling, electrical stimulation, laser treatments using high peak power and short pulse durations, ultrasound, and combinations thereof.
24. The method of claim 23 wherein the penetration enhancing procedure comprises microdermabrasion.
25. The method of claim 23 wherein the penetration enhancing procedure comprises exposing said tissue to ultrasound.
26. A method, comprising:
exposing acne bacteria to at least one source of narrowband, multi chromatic electromagnetic radiation having a power output of from about 0.5 mW to about 20 mW, wherein the narrowband, multichromatic electromagnetic radiation has at least one dominant emissive wavelength between about 300 nm and about 1400 nm, which approximately corresponds with an absorption maxima of the tissue, and wherein the exposing step comprises pulsing the source of narrowband, multichromatic electromagnetic radiation at least 2 times,
wherein the narrowband, multichromatic electromagnetic radiation has a bandwidth less than or equal to about +/ 100 nm around the at least one dominant emissive wavelength.
27. The method of claim 26 wherein the tissue is exposed to from about 2 to about 2000 pulses from the source of narrowband, multichromatic electromagnetic radiation.
28. The method of claim 27 wherein each pulse has a duration of from about 1 millisecond to about 1000 milliseconds.
29. The method of claim 28 wherein each pulse is separated from the next pulse by a time period of from about 1 to about 1000 milliseconds.
30. The method of claim 26 wherein the source of narrowband, multichromatic electromagnetic radiation is pulsed about 100 times for about 250 milliseconds per pulse with a separation of about 100 milliseconds between each pulse.
31. The method of claim 30 wherein the energy output of the source of narrowband, multichromatic electromagnetic radiation is about 4 mW.
32. The method of claim 26 comprising applying a photomodulation enhancing agent to the tissue containing or surrounding the acne bacteria prior to exposing said tissue to said source of narrowband, multichromatic electromagnetic radiation.
33. The method of claim 32 wherein said photomodulation enhancing agent comprises a composition have an active agent selected from the group consisting of at least one of Vitamin C, Vitamin E, Vitamin A, Vitamin K, Vitamin F, Retin A (Tretinoin), Adapalene, Retinal, Hydroquinone, Kojic acid, a growth factor, echinacea, an antibiotic, an antifungal, an antiviral, a bleaching agent, an alpha hydroxy acid, a beta hydroxy acid, salicylic acid, antioxidant triad compound, a seaweed derivative, a salt water derivative, an antioxidant, a phytoanthocyanin, epigallocatechin-3-ganate, a phytonutrient, a botanical product, a herbaceous product, a hormone, an enzyme, a mineral, a genetically engineered substance, a cofactor, a catalyst, an antiaging substance, insulin, trace elements (including ionic calcium, magnesium, etc), minerals, Rogaine, a hair growth stimulating substance, a hair growth inhibiting substance, a dye, a natural or synthetic melanin, a metalloproteinase inhibitor, praline, hydroxyprolire, an anesthetic substance, chlorophyll, copper chlorophyllin, chloroplasts, carotenoids, bacteriochlorophyll, phycobilins, carotene, xanthophyll, anthocyanin, and derivatives, subcomponents, and analogs of the above, both natural and synthetic, and mixtures thereof.
34. The method of claim 32 wherein the photomodulation enhancing agent is selected from the group consisting of chlorophyll, carotenoids, bacteriochlorophyll, phycobilins, porphyrins, derivatives thereof, and mixtures thereof.
35. The method of claim 32 further comprising subjecting the tissue to a penetration enhancing procedure after applying said photomodulation enhancing agent thereto and prior to exposing said tissue to said source of electromagnetic radiation.
36. The method of claim 35 wherein the penetration enhancing procedure comprises a procedure selected from the group consisting of enzyme peel, microderm abrasion, solvent stripping, tape stripping, scrubbing, laser ablation, laser vaporization, chemical peeling, electrical stimulation, laser treatments using high peak power and short pulse durations, ultrasound, and combinations thereof.
37. The method of claim 36 wherein the penetration enhancing procedure comprises microdermabrasion.
38. The method of claim 36 wherein the penetration enhancing procedure comprises exposing said tissue to ultrasound.