IP Library › Granted Patent US 9,233,097
Granted Patent B2
US 9,233,097 · App. 13/814,102 · Granted Jan 12, 2016

ST-246 liquid formulations

Inventors: Shanthakumar R. Tyavanagimatt (Corvallis, OR); Melialani A. C. L. Stone (Corvallis, OR); William C. Weimers (Corvallis, OR); Gopi Krishna Kasi (Corvallis, OR); Peter N. K. Samuel (Corvallis, OR); Tove Bolken (Keizer, OR); Dennis E. Hruby (Albany, OR)
Assignee: SIGA TECHNOLOGIES, INC.
A61K31/403A61K9/0014A61K9/0019A61K9/08A61K31/4035A61K31/715A61K31/724A61K39/00A61K47/10A61K47/40A61K47/48969
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Quick Facts
Patent No.
US 9,233,097
App. No.
13/814,102
Granted
Jan 12, 2016
Kind
B2
Abstract

The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.

Claims (5)

1. A liquid pharmaceutical formulation comprising a therapeutically effective amount of ST-246 and hydroxypropyl-β-cyclodextrin and/or sufobutyl-ether-β-cylodextrin, and further comprising one or more pharmaceutically acceptable ingredients.

2. The liquid pharmaceutical formulation of claim 1 , wherein said pharmaceutically acceptable ingredients are selected from the group consisting of carrier, excipient, diluent, additive, filler, lubricant and binder.

3. The liquid pharmaceutical formulation of claim 1 , wherein said hydroxypropyl-β-cyclodextrin is present in amounts from about 20% to about 40% by weight.

4. The liquid pharmaceutical formulation of claim 1 having a pH between about 3 and 10.

5. The liquid pharmaceutical formulation of claim 1 , wherein said hydroxypropyl-β-cyclodextrin has a degree of substitution of between about 4.0 to about 8.0.

Assignments (3)
RELEASE OF SECURITY INTEREST IN INTELLECTUAL PROPERTY AT REEL/FRAME NO. 40349/0219 Recorded Mar 13, 2020
From: CORTLAND CAPITAL MARKET SERVICES LLC
To: SIGA TECHNOLOGIES, INC.
Reel/Frame 052163/0014 →
SECURITY INTEREST Recorded Nov 16, 2016
From: SIGA TECHNOLOGIES, INC.
To: CORTLAND CAPITAL MARKET SERVICES, LLC
Reel/Frame 040349/0219 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 5, 2013
From: TYAVANAGIMATT, SHANTHAKUMAR R.; STONE, MELIALANI A.C.L.; WEIMERS, WILLIAM; KASI, KRISHNA GOPI; SAMUEL, PETER N.K.; BOLKEN, TOVE' C.; HRUBY, DENNIS E.
To: SIGA TECHNOLOGIES, INC.
Reel/Frame 030158/0860 →
Continuity (3)
Provisional Application 61370971 · Aug 5, 2010
Provisional Application 61450359 · Mar 8, 2011
Related Publication 20140011854A1 · Jan 9, 2014