IP Library › Granted Patent US 9,238,060
Granted Patent B2
US 9,238,060 · App. 14/176,330 · Granted Jan 19, 2016

Chimeric factor VII molecules

Inventors: Darrel W. Stafford (Carrboro, NC); Dengmin Feng (Chapel Hill, NC)
Assignee: The University of North Carolina at Chapel Hill
A61K38/4846C12N9/644C12N9/6437C12Y304/21021C12Y304/21022A61K38/00
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Quick Facts
Patent No.
US 9,238,060
App. No.
14/176,330
Granted
Jan 19, 2016
Kind
B2
Abstract

The present invention relates to chimeric Factor VII polypeptides and methods of using the same.

Claims (6)

1. A method for treating uncontrolled bleeding in a hemophiliac or non-hemophiliac subject in need of treatment, the method comprising:

administering to the subject a chimeric coagulation protein comprising:

a GLA domain selected from the group consisting of the GLA domain of Factor IX and the GLA domain of Protein S and an EGF-1 domain of Factor IX; and

EGF-2 and catalytic domains of Factor VII.

2. The method of claim 1 , wherein the uncontrolled bleeding is associated with a congenital, acquired, or induced defect.

3. The method of claim 2 , wherein the defect has an origin selected from cellular, physiological, or molecular.

Continuity (3)
Continuation 12823382 · Jun 25, 2010
Provisional Application 61220278 · Jun 25, 2009
Related Publication 20140302005A1 · Oct 9, 2014