Photosensitizer composition for treating skin disorders

1. A composition comprising:

(a) an active ingredient selected from the group of 5-aminolevulinic acid or a pharmaceutically acceptable salt or derivative thereof in an amount of 10-30% by wt; and

(b) a micelle-forming aqueous carrier in an amount of 40-60% by wt

comprising sodium lauryl sulfate, EDTA, cremaphor A 25, glycerin, polyoxyethylene, isopropyl alcohol, polyvinyl alcohol and sorbitol in an amount ranging from 0.1-10% by wt; an anesthetic in an amount of 0.1-10% by wt and selected from the group consisting of Lidocaine, bupivacaine, prilocaine, benzocaine, tetracaine, lanacaine, mepivacaine and combinations thereof; a non-fatty acid selected from the group consisting of hyaluronic acid in an amount of 0.1-2% by wt, lactic acid 1-5% by wt and glycolic acid 1-3% by wt; and

the balance of the carrier being water; and

(c) an acidic phase which imparts on the composition a pH of less than 7.

2. The composition according to claim 1 , wherein the carrier further comprises an absorption enhancer is selected from the group consisting of sodium lauryl sulfate, DMSO, bile salts, compound selected from the group comprising lecithin, hyaluronic acid, octylphenoxypolyethoxyethanol, glycolic acid, lactic acid, chamomile extract, cucumber extract, oleic acid, linoleic acid, linolenic acid, borage oil, evening of primrose oil, menthol, trihydroxy oxocholanyl glycine, glycerin, polyglycerin, lysine, polylysine, triolein, polyoxyethylene ethers, polidocanol alkyl ethers, chenodeoxycholate, deoxycholate, benzyl alcohol, carbomer 940, cholesterol, hydrogenated lecithin, polysorbate 80, propylene glycol, trolamine, vitamin E acetate, lidocaine, benzyl alcohol, carbomer 940, cholesterol, hydrogenated lecithin, polysorbate 80, propylene glycol, trolamine, vitamin E acetate, and combinations thereof.

3. The composition, of claim 1 wherein the active ingredient is present in a proportion of from 10% to 25% by weight based on the total weight of the composition.

4. The composition of claim 3 , wherein the composition is in the form of a gel and, based on the total weight of the composition, comprises from 10% to 15% of active ingredient, from 40 to 55% of carrier, with the remainder being water.

5. The composition of claim 3 , wherein the composition is in the form of a lotion or gel, and based on the total weight of the composition, comprises from 10 to 15% of active ingredient, and from 40 to 60% of carrier with the balance of the carrier being water.

6. The composition of claim 1 , wherein the composition additionally comprises cosmetic or pharmaceutical adjuvants.

7. The composition according to claim 1 , wherein the carrier comprises 0.1-2% HA, 0.1-2% Polyvinyl Alcohol, 1-3% glycolic acid, 1-5% lactic acid and 0.1-10% anaesthetic, based on the total weight of the composition.

8. The composition of claim 7 , wherein the anaesthetic is selected from the group consisting of Lidocaine, bupivacaine, prilocaine, benzocaine, tetracaine, lanacaine, mepivacaine and combination thereof.

9. The composition of claim 1 , additionally comprising an oxygen radical generating compound or oxygen-containing compound.

10. The composition as defined in claim 9 , comprising a compound selected from the group consisting of hydrogen peroxide, benzoyl peroxide and a perfluorocarbon.

11. A kit comprising a topically applicable composition as defined in claim 1 further comprising (a) an essentially light-impermeable sheet-like material, (b) means for attaching the sheet-like material to a site of application, and (c) means for applying the composition to a site of application.

12. The composition of claim 1 , wherein the carrier comprises 0.5% by wt sodium lauryl sulfate, 0.5% by wt EDTA, 1% by wt cremaphor A 25, 3% by wt glycerin, 0.5-1% by wt polyoxyethylene, 1-2% by wt isopropyl alcohol, 0.5% by wt polyvinyl alcohol and 0.5% by wt sorbitol.

13. The composition of claim 1 , wherein the carrier comprises 1-2% by wt of the anaesthetic.

14. The composition of claim 13 , wherein the anaesthetic is lidocaine.

15. The composition of claim 1 , wherein the composition additionally comprises cosmetic or pharmaceutical adjuvants.

16. The composition as defined in claim 1 , further comprising a compound selected from the group consisting of hydrogen peroxide, benzoyl peroxide and a perfluorocarbon.