Granted Patent B2

US 9,249,196 · App. 13/359,442 · Granted Feb 2, 2016

Inventors: Claire Fraser (Potomac, MD); Cesira Galeotti (Poggibonsi, IT); Guido Grandi (Segratf, IT); Erin Hickey (Palatine, IL); Vega Masignani (Siena, IT); Marirosa Mora (Siena, IT); Jeremy Petersen (Arlington, VA); Mariagrazia Pizza (Siena, IT); Rino Rappuoli (Vagliagli, IT); Giulio Ratti (Siena, IT); Vincenzo Scarlato (Colle Val D'Elsa, IT); Maria Scarselli (Siena, IT); Herve Tettelin (Gaithersburg, MD); J. Craig Venter (Potomac, MD)

Assignee: GlaxoSmithKline Biologicals SA

C07K14/22A61K38/00A61K39/00A61K39/095Y10S530/806Y10S530/825

Abstract

Claims (10)

1. A composition comprising an immunostimulatory effective amount of aluminum salt adjuvant and a purified polypeptide comprising a fragment of the amino acid sequence of SEQ ID NO: 2536, wherein the fragment comprises 18 or more consecutive amino acids from the amino acid sequence, and wherein the purified polypeptide is immunogenic.

2. The composition of claim 1 comprising the fragment, wherein the fragment comprises 20 or more consecutive amino acids from the amino acid sequence of SEQ ID NO: 2536.

3. The composition of claim 1 , in combination with a pharmaceutically acceptable carrier.

4. The composition of claim 2 , in combination with a pharmaceutically acceptable carrier.

5. The composition of claim 1 , in further combination with a pH buffering agent.

6. The composition of claim 2 , in further combination with a pH buffering agent.

7. The composition of claim 1 , wherein the composition is formulated as an injectable.

8. The composition of claim 1 , wherein the purified polypeptide is recombinant.

9. The composition of claim 1 , wherein the aluminum salt adjuvant comprises an aluminum hydroxide adjuvant.

10. The composition of claim 1 , wherein the aluminum salt adjuvant comprises an aluminum phosphate adjuvant.

Assignments (10)

Continuity (12)