RNA targeting compounds and methods for making and using same
View Patent ↗Disclosed are RNA targeting compounds, methods for using the subject RNA targeting compounds to treat myotonic dystrophy and other diseases are also disclosed.
1. A compound having the formula:
wherein i is an integer from 2 to 9; j is an integer from 0-4; k is an integer from 0-3; each Z 1 represents the same or different linking moiety; each R 1 is the same or different and represents an alkyl group or an aryl group; each Q 1 is the same or different and is selected from aminoglycoside sugars and bis-benzimidazoles; Q 2 is an unsubstituted or substituted alkyl group; and Q 3 is H or a substituted carbonyl group.
2. A compound according to claim 1 , wherein the compound has the following structure:
3. The compound according to claim 1 , wherein Q 3 has the formula —C(O)—R 4 , R 4 is
4. A compound according to claim 3 , wherein the compound has the following structure:
where FAM is a carboxyfluorescein.
5. A compound having the formula:
wherein i is an integer from 2 to 9; j is an integer from 0-4; k is an integer from 0-3; each Z 1 represents the same or different linking moiety; each R 1 is the same or different and represents an alkyl group or an aryl group; each Q 1 is the same or different and is selected from protein, polypeptides, carbohydrates, non-nucleic acid biopolymers, peptoids, whole cells, aminoglycoside sugars and bis-benzimidazoles; Q 2 is an unsubstituted or substituted alkyl group; and Q 3 is H or a substituted carbonyl group.
6. A compound having the formula:
wherein i is an integer from 2 to 9; j is an integer from 0-4; k is an integer from 0-3; each Z 1 represents the same or different linking moiety and has one of the following structure:
each R 1 is the same or different and represents an alkyl group or an aryl group; each Q 1 is the same or different and is selected from protein, polypeptides, carbohydrates, non-nucleic acid biopolymers, peptoids, whole cells, aminoglycoside sugars and bis-benzimidazoles; Q 2 is an unsubstituted or substituted alkyl group; and Q 3 is H or a substituted carbonyl group.