Organic compound nano-powder, method for producing the same and suspension
An organic compound nano-powder comprising a granular organic compound with an average particle diameter of 500 nm or less and a 90%-diameter of less than 1500 nm and a carbohydrate compound comprising at least any one of a sugar and a sugar alcohol and with amount of 0.3 times or more by mass relative to amount of the organic compound, a method for producing the same, and a suspension having the organic compound dispersed in a liquid dispersion medium in which the organic compound is insoluble or poorly soluble.
1. A method for producing an organic compound nano-powder comprising:
mixing a granular organic compound, a granular sugar compound comprising at least any one of a granular sugar and a granular sugar alcohol and with amount of 0.3 times or more by mass relative to amount of the organic compound, and liquid in which the organic compound is insoluble or poorly soluble in a kneader;
wet-milling the organic compound using the granular sugar compound as a grinding medium after the mixing so that an average particle diameter thereof becomes 500 nm or less and a 90%-diameter thereof becomes less than 1500 nm; and
wherein the wet-milling of the organic compound is carried out while kneading the mixture obtained after the mixing in a kneader.
2. The method for producing an organic compound nano-powder according to claim 1 , wherein the granular sugar compound is in an amount of 0.5 to 30 times by mass relative to amount of the organic compound.
3. The method for producing an organic compound nano-powder according to claim 1 , wherein the mixing is carried out with adding a physiologically acceptable polyol as liquid in which the organic compound is insoluble or poorly soluble.
4. The method for producing an organic compound nano-powder according to claim 1 , wherein a drying is carried out after the milling.
5. The method for producing an organic compound nano-powder according to claim 1 , wherein the granular sugar compound is one or more kinds selected from the group consisting of mannitol, maltitol, xylitol, erythritol, glucose, fructose, inositol, lactose, trehalose, cellobiose and dextrin.
6. The method for producing an organic compound nano-powder according to claim 1 , wherein a physiologically acceptable salt is further mixed in the process of the mixing.
7. The method for producing an organic compound nano-powder according to claim 6 , wherein the physiologically acceptable salt is sodium chloride.
8. The method for producing an organic compound nano-powder according to claim 1 , wherein the organic compound is one or more kinds selected from the group consisting of clarithromycin, fexofenadine hydrochloride, fluorometholone, curcuminoid, curcumin, rutin, mefenamic acid, acetaminophen, ibuprofen, amphotericin B, diclofenac sodium, indomethacin, felbinac, pranlukast hydrate, dexamethasone and fenofibrate.
9. The method for producing an organic compound nano-powder according to claim 1 , wherein the mass ratio of the granular sugar compound to the liquid is 1.75-to-1 or more.
10. The method for producing an organic compound nano-powder according to claim 1 , wherein the granular sugar compound comprises an average particle diameter of 10-631 microns.