Modulating apoptosis
The use and screening of modulators of apoptosis is disclosed. The modulators may be, for example, modulator of NF-κB activity. The modulators may be used, for example, in the treatment of NF-κB-mediated diseases, conditions, and injuries.
1. A method for protecting a mammal from ionizing radiation, comprising administering to a mammal in need thereof an amount of Salmonella flagellin effective to extend the survival of the mammal, wherein the flagellin is capable of inducing NF-κB activity.
2. The method of claim 1 , wherein the ionizing radiation is sufficient to cause gastrointestinal syndrome or hematopoietic syndrome.
3. The method of claim 1 , wherein the flagellin has a dose modification factor (DMF) value of greater than about 1.5 as assessed for 30-day survival.
4. The method of claim 1 , wherein the composition is administered in combination with a radioprotectant.
5. The method of claim 4 , wherein the radioprotectant is an antioxidant.
6. The method of claim 5 , wherein the antioxidant is selected from amifostine and vitamin E.
7. The method of claim 1 , wherein the radioprotectant is a cytokine.
8. The method of claim 7 , wherein the cytokine is stem cell factor.
9. The method of claim 1 , wherein the composition is administered in combination with a growth factor.
10. The method of claim 9 , wherein the growth factor is keratinocyte growth factor.
11. The method of claim 1 , wherein the composition is administered in combination with a steroid.
12. The method of claim 11 , wherein the steroid is 5-androstenediol.
13. The method of claim 1 , wherein the composition is administered in combination with ammonium trichloro(dioxoethylene-O,O′)tellurate.