IP Library Granted Patent US 9,297,796
Granted Patent B2
US 9,297,796 · App. 13/497,852 · Granted Mar 29, 2016

Bent nanowires and related probing of species

Inventors: Bozhi Tian (Cambridge, MA); Ping Xie (Needham, MA); Thomas J. Kempa (Somerville, MA); Charles M. Lieber (Lexington, MA); Itzhaq Cohen-Karni (Cambridge, MA); Quan Qing (Somerville, MA); Xiaojie Duan (Somerville, MA)
Assignee: President and Fellows of Harvard College
G01N33/48728B82Y10/00B82Y15/00H01L29/045H01L29/0665
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Quick Facts
Patent No.
US 9,297,796
App. No.
13/497,852
Granted
Mar 29, 2016
Kind
B2
Abstract

Kinked nanowires are used for measuring electrical potentials inside simple cells. An improved intracellular entrance is achieved by modifying the kinked nanowires with phospholipids.

Claims (44)

1. An article, comprising:

a nanoscale wire having at least one kink, wherein the nanoscale wire is a single crystal and at least a portion of a surface of the nanoscale wire is amphiphilic.

2. The article of claim 1 , wherein the nanoscale wire further comprises a coating.

3. The article of claim 2 , wherein the coating comprises a phospholipid.

4. The article of claim 1 , wherein the nanoscale wire is a semiconductor.

5. The article of claim 1 , wherein the nanoscale wire comprises a transistor.

6. The article of claim 1 , wherein the nanoscale wire is disposed on a substrate.

7. The article of claim 1 , wherein the nanoscale wire has a diameter less than 100 nm.

8. The article of claim 1 , wherein the nanoscale wire has a length greater than 1 micron.

9. The article of claim 1 , wherein the nanoscale wire has a length less than 100 nm.

10. The article of claim 1 , wherein the nanoscale wire is capable of fusing with a lipid bilayer.

11. The article of claim 10 , wherein the lipid bilayer is a cell membrane.

12. An article, comprising:

a nanoscale wire having at least one kink, wherein the nanoscale wire is a single crystal and at least a portion of a surface of the nanoscale wire is capable of fusing with a lipid bilayer.

13. The article of claim 12 , wherein the lipid bilayer is a cell membrane.

14. The article of claim 12 , wherein the nanoscale wire is capable of fusing with at least two lipid bilayers.

15. The article of claim 12 , wherein the nanoscale wire further comprises a coating.

16. The article of claim 15 , wherein the coating comprises a phospholipid.

17. The article of claim 12 , wherein the nanoscale wire is a semiconductor.

18. The article of claim 12 , wherein the nanoscale wire comprises a field effect transistor.

19. The article of claim 12 , wherein the nanoscale wire is disposed on a substrate.

20. The article of claim 12 , wherein the nanoscale wire has a diameter less than 100 nm.

21. The article of claim 12 , wherein the nanoscale wire has a length greater than 1 micron.

22. The article of claim 12 , wherein the nanoscale wire has a length less than 100 nm.

23. The article of claim 12 , wherein the nanoscale wire is amphiphilic.

24. An article, comprising:

a nanoscale wire having at least one kink, wherein the nanoscale wire is a single crystal and at least a portion of the nanoscale wire is capable of penetrating a lipid bilayer using chemical interactions.

25. The article of claim 24 , wherein the nanoscale wire further comprises a coating.

26. The article of claim 25 , wherein the coating comprises a phospholipid.

27. The article of claim 24 , wherein the lipid bilayer is a cell membrane.

28. The article of claim 24 , wherein the nanoscale wire is capable of penetrating at least two lipid bilayers.

29. The article of claim 24 , wherein the nanoscale wire is a semiconductor.

30. The article of claim 24 , wherein the nanoscale wire comprises a field effect transistor.

31. The article of claim 24 , wherein the nanoscale wire is disposed on a substrate.

32. The article of claim 24 , wherein the nanoscale wire has a diameter less than 100 nm.

33. The article of claim 24 , wherein the nanoscale wire has a length greater than 1 micron.

34. The article of claim 24 , wherein the nanoscale wire has a length less than 100 nm.

35. The article of claim 24 , wherein the nanoscale wire is amphiphilic.

36. The article of claim 1 , wherein the kink comprises a transition between a first substantially straight portion of the wire and a second substantially straight portion of the wire, wherein the transition region may have a linear length that is less than about 5% of the linear lengths of the substantially straight portions surrounding the transition region.

37. The article of claim 1 , wherein the kink has an angle of about 120°.

38. The article of claim 12 , wherein the kink comprises a transition between a first substantially straight portion of the wire and a second substantially straight portion of the wire, wherein the transition region may have a linear length that is less than about 5% of the linear lengths of the substantially straight portions surrounding the transition region.

39. The article of claim 12 , wherein the kink has an angle of about 120°.

40. The article of claim 24 , wherein the kink comprises a transition between a first substantially straight portion of the wire and a second substantially straight portion of the wire, wherein the transition region may have a linear length that is less than about 5% of the linear lengths of the substantially straight portions surrounding the transition region.

41. The article of claim 24 , wherein the kink has an angle of about 120°.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 31, 2012
From: LIEBER, CHARLES M.; XIE, PING; QING, QUAN; TIAN, BOZHI; KEMPA, THOMAS J.; COHEN-KARNI, ITZHAQ TZAHI; DUAN, XIAOJIE
To: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Reel/Frame 028682/0593 →
CONFIRMATORY LICENSE Recorded Apr 23, 2012
From: HARVARD UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 028093/0126 →
Continuity (3)
Provisional Application 61245641 · Sep 24, 2009
Provisional Application 61326108 · Apr 20, 2010
Related Publication 20120267604A1 · Oct 25, 2012