Nanostructured surfaces for biomedical/biomaterial applications and processes thereof
A medical device includes a textured surface having a predetermined nanostructure, wherein the nanostructure is less than about 500 nanometers in a broadest dimension. The textures nanostructure surface reduces friction between the medical device and biological tissue.
1. A mold for fabricating nano-structures for medical applications, the mold comprising:
a first surface defining nano-structures configured for fabricating medical articles for treating biologic tissues or conditions,
wherein the nano-structures are less than 500 nm in a dimension, and
wherein the mold comprises an oligomer produced from polymerization of monomers selected from the group consisting of trifluorochloroethylene, trifluoroethylene, hexafluoro-iso-propyl (meth)acrylate, 1H,1H,3H-hexafluorobutyl(meth)acrylate, 1H,1H,5H-octafluoropentyl (meth)acrylate, pentafluorophenyl (meth)acrylate, perfluoro(methyl vinyl ether), 1,1-dihydroperfluorobutyl (meth)acrylate, and combinations thereof, and a functional monomer included in the polymerization of the oligomer, wherein the functional monomer is selected from the group consisting of hydroxyethyl(meth)acrylate, (meth)acrylic acid, vinyl acetate, vinyl sulfonic acid, styrene sulfonic acid, 4-hydroxy styrene, 2-acrylamido-2-methyl propane sulfonate, maleic anhydride, glycidyl methacrylate, isocyanatoethyl methacrylate, and combinations thereof.
2. The mold of claim 1 , further comprising a surfactant for adjusting wetting characteristics of the mold.
3. The mold of claim 2 , wherein the surfactant is selected from the group consisting of acetylenic alcohol, acetylenic diol, polypropylene oxide), poly(butylene oxide), silicone-poly(ethylene oxide) surfactant, and combinations thereof.
4. The mold of claim 2 , wherein the surfactant is selected from the group consisting of a fluorinated hydrocarbon with sulfonic acid end or pendant groups, a fluorinated hydrocarbon with carboxylic acid end or pendant groups, and combinations thereof.
5. The mold of claim 2 , wherein the surfactant is selected from the group consisting of perfluorooctanoic acid, perfluorooctane sulfonic acid, and combinations thereof.
6. The mold of claim 1 , wherein the medical articles comprise a biocompatible polymer, a protein, a biological molecule, or combinations thereof.
7. The mold of claim 1 , wherein the nano-structures defined in the first surface comprise cavities having a broadest dimension of greater than about 1000 nm and a second dimension less than 500 nm.
8. The mold of claim 1 , wherein the nano-structures defined in the first surface comprise cavities having a broadest dimension greater than about 2000 nm and a second dimension less than 500 nm.
9. A system for fabricating nano-structures for medical applications, the system comprising:
a mold having a first surface defining nano-structures for molding articles therefrom,
wherein the nano-structures are less than 500 nm in a dimension,
wherein the mold comprises an oligomer produced from polymerization of monomers selected from the group consisting of trifluorochloroethylene, trifluoroethylene, hexafluoro-iso-propyl (meth)acrylate, 1H,1H,3H-hexafluorobutyl(meth)acrylate, 1H,1H,5H-octafluoropentyl (meth)acrylate, pentafluorophenyl (meth)acrylate, perfluoro(methyl vinyl ether), 1,1-dihydroperfluorobutyl (meth)acrylate, and combinations thereof, and a functional monomer included in the polymerization of the oligomer, wherein the functional monomer is selected from the group consisting of hydroxyethyl(meth)acrylate, (meth)acrylic acid, vinyl acetate, vinyl sulfonic acid, styrene sulfonic acid, 4-hydroxy styrene, 2-acrylamido-2-methyl propane sulfonate, maleic anhydride, glycidyl methacrylate, isocyanatoethyl methacrylate, and combinations thereof; and
a biomaterial configured to be molded by the mold and form a medical article that treats or prevents a biologic tissue or condition.
10. The system of claim 9 , wherein the mold further comprises a surfactant, wherein the surfactant controls wetting characteristics of the mold.
11. The system of claim 10 , wherein the surfactant is selected from the group consisting of acetylenic alcohol, acetylenic diol, polypropylene oxide), poly(butylene oxide), silicone-poly(ethylene oxide) surfactant, a fluorinated hydrocarbon with sulfonic acid end or pendant groups, a fluorinated hydrocarbon with carboxylic acid end or pendant groups, perfluorooctanoic acid, perfluorooctane sulfonic acid, and combinations thereof.
12. The system of claim 9 , wherein the medical articles comprise a biocompatible polymer, a protein, a biological molecule, or combinations thereof.
13. The system of claim 9 , wherein the nano-structures defined in the first surface of the mold comprise cavities having a broadest dimension of greater than about 1000 nm and a second dimension less than 500 nm.
14. The system of claim 9 , wherein the nano-structures defined in the first surface of the mold comprise cavities having a broadest dimension of greater than about 2000 nm and a second dimension less than 500 nm.