Substituted xanthine derivatives
This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentifylline and related compounds are beneficial.
1. A compound of Formula A:
or pharmaceutically acceptable salts thereof, wherein
each of X 1a , X 1b , X 2a , and X 2b is deuterium;
each of X 3a , X 3b , X 4a , X 4b , X 5a , X 5b and X 6 is hydrogen;
R 1 is —CD 3 ; and
each of R 2 and R 3 is independently CH 3 or CD 3 .
2. The compound of claim 1 , wherein R 3 and R 2 are each —CD 3 .
3. The compound of claim 1 , wherein R 3 and R 2 are each —CH 3 .
4. The compound of claim 1 , wherein R 3 is —CH 3 and R 2 is —CD 3 .
5. The compound of claim 1 , wherein R 2 is —CH 3 and R 3 is —CD 3 .
6. The compound of claim 1 , wherein any atom not designated as deuterium is present at its natural isotopic abundance.
7. The compound of claim 1 , wherein the compound is a compound selected from the group consisting of the compounds of Table 1 and wherein any atom not designated as deuterium is present at its natural isotopic abundance:
TABLE 1
X 1a =
X 2a =
X 3a =
X 4a =
X 5a =
Cmpd
X 1b
X 2b
X 3b
X 4b
X 5b
X 6
R 1
R 2
R 3
102
D
D
H
H
H
H
CD 3
CH 3
CH 3
103
D
D
H
H
H
H
CD 3
CD 3
CD 3
110
D
D
H
H
H
H
CD 3
CH 3
CD 3
111
D
D
H
H
H
H
CD 3
CD 3
CH 3
or a pharmaceutically acceptable salt thereof.
8. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
9. A method of therapeutic or prophylactic treatment of intermittent claudication in a patient in need thereof, comprising administering to the patient an effective amount of a compound of claim 1 .