Methods for treating epithelium trauma of the intestinal mucosa using interleukin-1 receptor antagonist
The invention provides a use of the interleukin-1 receptor antagonist protein for preparing a medicament for preventing or treating epithelium trauma of the intestinal mucosa, wherein the protein is selected from: (a) a protein having an amino acid sequence as shown in SEQ ID NO: 1; (b) a protein which has a sequence having at least 70% homology with the amino acid sequence in the (a) and has the effect of preventing or treating epithelium trauma of the intestinal mucosa. The invention also provides a pharmaceutical composition comprising the protein (a) or (b) as the active component.
1. A method for treating chemotherapeutic agent-induced epithelium trauma of the intestinal mucosa in a subject in need thereof, comprising administering an effective amount of a protein selected from a group consisting of:
a. a protein having the amino acid sequence of SEQ ID NO: 1; or
b. a protein having the amino acid sequence of SEQ ID NO: 2.
2. The method of claim 1 , wherein the chemotherapeutic agent comprises an alkylating agent, antimetabolite, antibiotic, plant-derived anticancer agent, hormone, metal complex, or protein.
3. The method of claim 2 , wherein the chemotherapeutic agent is cyclophosphamide or 5-fluorouracil.
4. The method of claim 1 , wherein the intestinal mucosa is mucosa of the small intestine.
5. The method of claim 1 , wherein the capacity to treat chemotherapeutic agent-induced epithelium trauma of the intestinal mucosa comprises the capacity to prevent the reduction of villus length, crypt length, crypt depth, or crypt width.
6. A method of ameliorating the symptoms of chemotherapeutic agent-induced epithelium trauma of the intestinal mucosa in a subject in need thereof, comprising administering an effective amount of a protein selected from a group consisting of:
a. a protein having the amino acid sequence of SEQ ID NO: 1; or
b. a protein having the amino acid sequence of SEQ ID NO: 2.
7. The method of claim 6 , wherein the symptoms of chemotherapeutic agent-induced epithelium trauma of the intestinal mucosa comprise one or more of diarrhea, weight loss, and shortened survival.