Topical treatment of radiation dermatitis using hamelia patens
Topical compositions are provided useful for treating radiation dermatitis. The compositions comprise an extract of the plant Hamelia patens and are applied topically to skin having radiation dermatitis to relieve symptoms thereof.
1. A method for alleviating symptoms induced by external beam irradiation resulting from treating cancers with radiation on the skin of a human subject, which method comprises topically applying a composition containing a Hamelia patens extract to an affected skin area of said subject in an effective amount and frequency for alleviation of said symptoms.
2. The method according to claim 1 , wherein said composition is in any form selected from the group consisting of: salves, creams, ointments, and lotions.
3. The method according to claim 1 wherein said composition comprises any carrier selected from the group consisting of: water; saline solution, any C1 to C4 alcohol; any glyceryl ester oil; and any mineral oil.
4. The method according to claim 1 wherein said composition comprises a pharmaceutically-acceptable carrier.
5. The method according to claim 1 wherein said extract is an aqueous extract.
6. The method according to claim 1 wherein said extract is a non-aqueous extract.
7. The method according to claim 1 wherein said composition comprises a nanoparticle.
8. The method according to claim 7 wherein said nanoparticle is selected from the group consisting of: solid core nanoparticles, hollow core nanoparticles, lipid nanoparticles, PEG nanoparticles, and chitosan nanoparticles, including mixtures thereof.
9. The method according to claim 1 wherein said composition comprises a liposome.
10. The method according to claim 1 wherein said extract comprises an effective symptom-reducing amount of at least one material selected from the group consisting of: alkaloids, 2-alpha-hydroxyursolic acid, apigenin-7-o-beta d-glucuronide, aricine, catequine, 19-alphahydroxy Asiatic acid, 24-methylenecycloartane-3β-ol, 24-methylcycloart-24-en-3β-ol,2E-3,7,11,15,19-pentamethyl-2-eicosane-1-ol, ephedrine, flavonones, 2′-5-5′-7-tetrahydroxy-7-o-rutinoside, isomaruquine, isopteropodine, maruquine, the methyl ester of maruquine, mitraphylline, narirutin, narirutin (2r), narirutin (2s), oxindole alkaloids, oxindole aricine, palmirine, pigenin-7-o-beta D-glucuronide, pomolic acid, pteropodine, rumberine, rosmarinic acid, rotundic acid, rumberine, rutin, seneciophylline, β-sitosterol, speciophylline, stigmast-4-en-3-3-dione, stigmast-4-en-3-6-dione, stigmasterol, tannins, tormentic acid, uncarine F, and ursolic acid, including any mixtures thereof.
11. The method according to claim 10 wherein said composition comprises all of said materials recited in said group.
12. The method according to claim 10 wherein each material selected to be present in said composition is independently selected to be present in any amount between 0.05% by weight and 30% by weight based on the total weight of said composition.
13. The method according to claim 1 wherein said symptoms include at least one symptom selected from the group consisting of: chronic skin ulceration, chronic dermatitis, skin inflammation, and skin rashes.
14. A method for alleviating symptoms induced by external beam irradiation resulting from treating cancers with radiation on the skin of a human subject, which method comprises topically applying a composition containing a Hamelia patens extract to an affected skin area of said subject.
15. The method according to claim 14 , wherein said composition is in any form selected from the group consisting of: salves, creams, ointments, and lotions.
16. The method according to claim 14 wherein said composition comprises any carrier selected from the group consisting of: water; saline solution, any C1 to C4 alcohol; any glyceryl ester oil; and any mineral oil.
17. The method according to claim 14 wherein said composition comprises a pharmaceutically-acceptable carrier.
18. The method according to claim 14 wherein said extract is an aqueous extract.
19. The method according to claim 14 wherein said extract is a non-aqueous extract.
20. The method according to claim 14 wherein said symptoms include at least one symptom selected from the group consisting of: chronic skin ulceration, chronic dermatitis, skin inflammation, and skin rashes.