Method of treating cancer
The invention provides a method for treating cancer using a coadministration strategy that combines local codelivery of a therapeutic agent and an intracellular penetration enhancing agent, and optionally in further combination with local administration of an immunotherapeutic agent, such as a cancer vaccine or NKT agonist. The invention also provides a method for treating cancer using an intracellular penetration enhancing agent. The methods of the invention aim to substantially kill and/or destroy the target tumor cells, as well as those cancerous cells that have metastasized to other parts of the body.
1. A method of treating cancer in a subject in need of treatment, comprising: administering intratumorally an aqueous formulation including a therapeutically effective amount of a therapeutic agent and an intracellular permeation enhancing agent, wherein the formulation comprises cisplatin with N-(8[2-hydroxybenzoyl]amino)octanoic acid or cisplatin and vinblastine with N-(8[2-hydroxybenzoyl]amino)octanoic acid.
2. The method claim 1 , wherein the formulation is dosed at between 0.1 ml per cc of tumor volume and 1 ml per cc of tumor volume.
3. The method claim 1 , wherein the formulation comprises about 0.5 mg/ml of cisplatin with about 10 mg/ml of N-(8[2-hydroxybenzoyl]amino)octanoic acid or about 0.5 mg/ml of cisplatin and about 0.1 mg/ml of vinblastine with about 10 mg/ml of N-(8[2-hydroxybenzoyl]amino)octanoic acid.