Device and method for controlling injection of liquid embolic composition
A liquid embolic delivery system is provided for trapping an injected liquid embolic composition to prevent the liquid embolic from solidifying or otherwise passing outside of an embolization area. The delivery system includes a catheter for delivery of a liquid embolic composition and a containment member positioned at a distal end of the catheter which is shaped to trap the liquid embolic composition delivered through the lumen of the catheter. The containment member is formed as a brush, nest, sponge, swab, flexible sack, or other shape into and around which the liquid embolic composition is injected. The liquid embolic composition is trapped or meshes with the containment member during solidification containing the liquid embolic and preventing the embolic composition from passing into the blood stream.
1. A system comprising:
an inner catheter defining an inner catheter lumen;
an outer catheter defining an outer catheter lumen and a plurality of side ports, wherein the outer catheter surrounds the inner catheter, a distal end of the outer catheter forming a fluid tight seal with an exterior surface of the inner catheter when a distal end of the inner catheter extends past the distal end of the outer catheter, wherein the inner catheter is slideable with respect to the outer catheter to adjust a distance between the distal end of the inner catheter and the side ports;
a liquid embolic composition source fluidically connected to the inner catheter lumen; and
a disruption fluid source fluidically connected to the outer catheter lumen, the disruption fluid comprising saline, a contrast medium, or a mixture of saline and the contrast medium.
2. The system of claim 1 , wherein the inner catheter and the outer catheter each comprises a radiopaque marker.
3. The system of claim 1 , further comprising a radiopaque marker between the inner catheter and the outer catheter.
4. The system of claim 1 , further comprising a valve at the distal end of the outer catheter, wherein the valve is configured to allow the outer catheter to slide over the inner catheter in an axial direction without the leakage of fluid from the outer catheter lumen.
5. The system of claim 1 , wherein the outer catheter defines one row of side ports.
6. The system of claim 1 , wherein the outer catheter defines a plurality of rows of side ports, each row of side ports being axially spaced from an adjacent row of side ports.
7. The system of claim 1 ,
wherein the disruption fluid comprises the saline.
8. The system of claim 1 , further comprising:
a liquid embolic composition disposed within the inner catheter lumen; and
a disruption fluid disposed within the outer catheter lumen.
9. The system of claim 1 , further comprising:
a liquid embolic composition disposed within the inner catheter lumen; and
saline disposed within the outer catheter lumen.
10. The system of claim 1 , wherein the disruption fluid comprises the contrast medium.
11. The system of claim 1 , wherein the disruption fluid comprises the mixture of saline and the contrast medium.
12. A method comprising:
guiding a delivery system to a target location within a patient, the delivery system comprising:
an inner catheter defining an inner catheter lumen; and
an outer catheter defining an outer catheter lumen and a plurality of side holes, wherein the outer catheter surrounds the inner catheter, a distal end of the outer catheter forming a fluid tight seal with an exterior surface of the inner catheter, wherein the inner catheter is slideable with respect to the outer catheter to adjust a distance between a distal tip of the inner catheter and the side ports;
delivering a disruption fluid via the outer catheter lumen and the side holes defined by the outer catheter, the disruption fluid comprising saline, a contrast medium, or a mixture of saline and the contrast medium; and
delivering a liquid embolic material via the inner catheter lumen.
13. The method of claim 12 , wherein guiding the delivery system to the target location comprises positioning a distal end of the inner catheter within a dome of an aneurysm.
14. The method of claim 12 , wherein guiding the delivery system to the target location comprises positioning the side holes defined by the outer catheter inside and outside a neck of an aneurysm.
15. The method of claim 12 , wherein guiding the delivery system to the target location comprises sliding the inner catheter with respect to the outer catheter to adjust a distance between a distal tip of the inner catheter and the side holes.
16. The method of claim 12 , wherein the disruption fluid comprises the saline.
17. The method of claim 12 , wherein the disruption fluid comprises the contrast medium.
18. The method of claim 12 , wherein the disruption fluid comprises the mixture of saline and the contrast medium.