Methods and compositions related to cyclic peptide synthesis
Disclosed are compositions and methods for cyclization of polymers such as peptides.
1. A peptide comprising an amino acid segment comprising:
the amino acid sequence of GLEAS(N 1 )AYDGVEPS(N 2 )AYDGE,
an amino acid sequence at least about 90% identical to the amino acid sequence of GLEAS(N 1 )AYDGVEPS(N 2 )AYDGE, or
the amino acid sequence of GLEAS(N 1 )AYDGVEPS(N 2 )AYDGE having one or more conservative amino acid substitutions;
wherein N 1 and/or N 2 comprises an amino acid sequence,
wherein N 1 or N 2 do not comprise one or more of the amino acids A, C, I, F, L, P, S, T, or V.
2. The peptide of claim 1 , wherein the amino acid sequence of N 1 comprises less than 100 amino acids.
3. The peptide of claim 1 , wherein the amino acid sequence of N 1 comprises less than 50 amino acids.
4. The peptide of claim 1 , wherein the amino acid sequence of N 1 comprises less than 20 amino acids.
5. The peptide of claim 1 , wherein the amino acid sequence of N 1 comprises less than 10 amino acids.
6. The peptide of claim 1 , wherein the amino acid sequence of N 2 comprises less than 100 amino acids.
7. The peptide of claim 1 , wherein the amino acid sequence of N 2 comprises less than 50 amino acids.
8. The peptide of claim 1 , wherein the amino acid sequence of N 2 comprises less than 20 amino acids.
9. The peptide of claim 1 , wherein the amino acid sequence of N 2 comprises less than 10 amino acids.
10. A peptide comprising an amino acid segment comprising:
the amino acid sequence of GLEAS(N 1 )AYDGVEPS(N 2 )AYDGE,
an amino acid sequence at least about 90% identical to the amino acid sequence of GLEAS(N 1 )AYDGVEPS(N 2 )AYDGE, or
the amino acid sequence of GLEAS(N 1 )AYDGVEPS(N 2 )AYDGE having one or more conservative amino acid substitutions;
wherein N 1 and N 2 comprises an amino acid sequence,
wherein N 1 and N 2 do not comprise one or more of the amino acids A, C, I, F, L, P, S, T, or V.
11. The peptide of claim 10 , wherein the amino acid sequence of N 1 comprises less than 100 amino acids.
12. The peptide of claim 10 , wherein the amino acid sequence of N 1 comprises less than 50 amino acids.
13. The peptide of claim 11 , wherein the amino acid sequence of N 1 comprises less than 20 amino acids.
14. The peptide of claim 10 , wherein the amino acid sequence of N 1 comprises less than 10 amino acids.
15. The peptide of claim 10 , wherein the amino acid sequence of N 2 comprises less than 100 amino acids.
16. The peptide of claim 10 , wherein the amino acid sequence of N 2 comprises less than 50 amino acids.
17. The peptide of claim 10 , wherein the amino acid sequence of N 2 comprises less than 20 amino acids.
18. The peptide of claim 10 , wherein the amino acid sequence of N 2 comprises less than 10 amino acids.
19. The peptide of claim 10 , wherein one or more of the amino acids is functionalized.