Anti-TNFα antibody
An antibody that binds TNF α and neutralizes its activity is provided. In certain cases, the antibody comprises: a) a heavy chain variable domain comprising an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO. 1, and b) a light chain variable domain comprising an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID No. 2.
1. An antibody, comprising:
a) a heavy chain variable domain comprising an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO. 1 ; and
b) a light chain variable domain comprising an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID No. 2,
wherein the antibody binds TNFα.
2. The antibody of claim 1 , wherein said antibody is a monovalent antibody.
3. The antibody of claim 1 , wherein said antibody is a bivalent antibody.
4. The antibody of claim 1 , wherein said antibody is a single chain antibody.
5. The antibody of claim 1 , wherein said antibody is a monoclonal antibody.
6. The antibody of claim 1 , wherein said antibody comprises a single antigen binding arm and an Fc region.
7. The antibody of claim 1 , wherein said antibody is humanized.
8. The antibody of claim 1 , wherein the antibody is conjugated to an agent.
9. The antibody of claim 1 , wherein said heavy chain variable domain comprises CDR regions that are identical to those shown in FIG. 1 and said light chain variable domain comprises CDR regions that are identical to those shown in FIG. 1 and wherein any changes in the amino acid sequence of said antibody relative to SEQ ID NOs: 1 and 2 occur in framework sequence.
10. The antibody of claim 1 , where said antibody comprises CDRs that are otherwise identical to the CDRs of the antibody shown in FIG. 1 except for up to four amino acid substitutions in said CDRs.
11. A pharmaceutical composition comprising the antibody of claim 1 and a pharmaceutically acceptable carrier.
12. The antibody of claim 1 , wherein said antibody comprises
a) a heavy chain variable domain comprising an amino acid sequence that is identical to the amino acid sequence of SEQ ID NO. 1; and
b) a light chain variable domain comprising an amino acid sequence that is identical to the amino acid sequence of SEQ ID No. 2,
wherein the antibody binds TNFα.