Substituted pyrimidines for mobilizing cells expressing a type 4 CXC chemokine receptor
A method of mobilizing cells expressing the type 4 CXC chemokine receptor into the peripheral circulation by contacting them with an effective amount of a compound of formula (I) shown below (each variable in the formula being defined in the Specification): The method can be used to treat cancer and myocardial infarction.
1. A method for mobilizing cancer cells, endothelial progenitor cells, mesenchymal stem cells and hematopoietic stem cells expressing a CXCR4 chemokine receptor into the peripheral circulation, the method comprising contacting the cells with an effective amount of a compound selected from the group consisting of:
2. The method of claim 1 , wherein the compound is:
3. A method for sensitizing a cancer cell in a subject to a chemotherapy agent, the method comprising administering to the subject in need thereof an effective amount of a compound selected from the group consisting of:
4. The method of claim 3 , wherein the cancer cell is selected from the group consisting of a breast cancer cell, a lung cancer cell, and a prostate cancer cell.
5. The method of claim 3 , wherein the cancer cell is selected from the group consisting of an acute myelogenous leukemia cell and acute lymphoblastic leukemia cell.
6. The method of claim 3 , where the compound is:
7. The method of claim 4 , where the compound is:
8. The method of claim 5 , wherein the compound is:
9. A method for treating myocardial infarction in a subject, the method comprising administering to the subject in need thereof an effective amount of a compound selected from the group consisting of:
10. The method of claim 9 , wherein the compound is: