IP Library Granted Patent US 9,409,011
Granted Patent B2
US 9,409,011 · App. 14/320,316 · Granted Aug 9, 2016

Method of constructing an implantable microelectrode array

Inventors: Yu-Chong Tai (Pasadena, CA); Mandheerej S. Nandra (Pasadena, CA); Joel W. Burdick (Pasadena, CA); Damien Craig Rodger (South Pasadena, CA); Andy Fong (Los Angeles, CA); Victor Reggie Edgerton (Los Angeles, CA); Roland R. Roy (Playa Vista, CA); Yury Gerasimenko (Los Angeles, CA); Igor Lavrov (Rancho Palos Verdes, CA); Susan J. Harkema (Louisville, KY); Claudia A. Angeli (Louisville, KY)
Assignees: California Institute of Technology; University of Louisville Research Foundation, Inc.; The Regents of the University of California
A61N1/0551A61N1/0553A61N1/0558
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Quick Facts
Patent No.
US 9,409,011
App. No.
14/320,316
Granted
Aug 9, 2016
Kind
B2
Abstract

An implantable electrode array assembly configured to apply electrical stimulation to the spinal cord. A substantially electrically nonconductive layer of the device has a first portion positionable alongside the spinal cord that includes a plurality of first openings. The layer has a second portion that includes a plurality of second openings. Electrodes and traces are positioned inside a peripheral portion of a body portion of the device and alongside the layer. At least one of the first openings is adjacent each of the electrodes to provide a pathway through which the electrode may provide electrical stimulation to the spinal cord. At least one of the second openings is adjacent each of the traces to provide a pathway through which the trace may receive electrical stimulation. At least one trace is connected to each electrode and configured to conduct electrical stimulation received by the trace(s) to the electrode.

Claims (21)

1. A method of constructing an implantable electrode array assembly, the method comprising:

applying electrically conductive material to a frame layer forming a patterned layer of electrically conductive material defining a plurality of electrodes and a plurality of traces, at least one trace being connected to each of the plurality of electrodes, wherein at least a portion of the electrically conductive material is applied to a sacrificial material, wherein the portion of the conductive material is removed with the sacrificial material;

forming a first layer of a substantially electrically nonconductive material, the first layer being adjacent the patterned layer;

forming a plurality of first openings in the first layer, the first openings providing access to the plurality of electrodes through the first layer, a different grid defining portion of the first openings being adjacent each of the electrodes, each grid defining portion exposing a plurality of contacts of the electrode to which the grid defining portion is adjacent; and

forming a plurality of second openings in the first layer, the second openings providing access to the plurality of traces through the first layer.

2. The method of claim 1 , further comprising:

positioning a sacrificial layer on a substrate;

forming a second layer of a substantially electrically nonconductive material on the sacrificial layer; the patterned layer being positioned on the second layer; and

removing the sacrificial layer to thereby release the second layer from the substrate.

3. The method of claim 2 , further comprising:

forming the frame layer on the substrate, the frame layer being underneath the second layer, the frame layer at least partially defining a frame around the patterned layer.

4. The method of claim 2 , wherein the first and second layers are each formed from at least one of parylene-A, parylene-C, parylene-AM, parylene-F, paryleneN, and parylene-D.

5. The method of claim 2 , wherein the first and second layers are formed from the same material.

6. The method of claim 2 , wherein the patterned layer is formed on the second layer using a metal deposition technology.

7. The method of claim 6 , wherein the metal deposition technology is e-beam evaporation.

8. The method of claim 2 , wherein the sacrificial layer comprises a photoresist material.

9. The method of claim 2 , wherein the substrate is a silicon wafer.

10. The method of claim 2 , further comprising:

applying a coating to at least a portion of the second layer and at least a portion of the first layer.

11. The method of claim 1 , wherein the plurality of first openings are etched in the first layer.

12. The method of claim 1 , wherein the plurality of second openings are etched in the first layer.

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 26, 2016
From: TAI, YU-CHONG; NANDRA, MANDHEEREJ S.; BURDICK, JOEL W.; RODGER, DAMIEN CRAIG; FONG, ANDY
To: CALIFORNIA INSTITUTE OF TECHNOLOGY
Reel/Frame 040141/0538 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 26, 2016
From: HARKEMA, SUSAN J.; ANGELI, CLAUDIA A.
To: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
Reel/Frame 040141/0653 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 26, 2016
From: EDGERTON, VICTOR REGGIE; GERASIMENKO, YURY; LAVROV, IGOR; ROY, ROLAND R.
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 040141/0785 →
CONFIRMATORY LICENSE Recorded Jan 12, 2016
From: CALIFORNIA INSTITUTE OF TECHNOLOGY
To: US ARMY, SECRETARY OF THE ARMY
Reel/Frame 037484/0290 →
CONFIRMATORY LICENSE Recorded Aug 20, 2014
From: CALIFORNIA INSTITUTE OF TECHNOLOGY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 033577/0407 →
Continuity (4)
Division 13946338 · Jul 19, 2013
Continuation PCTUS2012022257 · Jan 23, 2012
Provisional Application 61435188 · Jan 21, 2011
Related Publication 20140316503A1 · Oct 23, 2014