Vascular closure device with biodegradable anchor
This disclosure pertains to controllably bioabsorbable devices, particularly anchors for vascular closure plugs and to methods of use thereof.
1. A bioabsorbable anchor for a vascular closure device comprising:
a magnesium anchor;
a biodegradable polymer coating associated with the magnesium anchor;
a conductive element connected to the magnesium anchor; and
a biodegradable electroactive polymer associated with one or more of the magnesium anchor, the biodegradable polymer, and the conductive element.
2. The bioabsorbable anchor of claim 1 , wherein the biodegradable electroactive polymer includes poly(3,4-ethylenedioxythiophene).
3. The bioabsorbable anchor of claim 1 , wherein the biodegradable polymer coating includes at least one of polylactic acid, polyglycolic acid, or a combination of polylactic acid and polyglycolic acid.
4. The bioabsorbable anchor of claim 1 , wherein the biodegradable polymer coating further comprises a heteropolyacid.
5. The bioabsorbable anchor of claim 1 , wherein the magnesium anchor comprises magnesium foam.
6. The bioabsorbable anchor of claim 5 , wherein the magnesium foam further comprises a heteropolyacid.
7. The bioabsorbable anchor of claim 1 , wherein the magnesium anchor is coated with at least one of polylactic acid, polyglycolic acid, or a combination of polylactic acid and polyglycolic acid.
8. The bioabsorbable anchor of claim 7 , wherein the coated magnesium anchor is further coated with a heteropolyacid.
9. The bioabsorbable anchor of claim 1 , wherein the conductive element connected to the magnesium anchor is coated with a biodegradable polymer.
10. The bioabsorbable anchor of claim 1 , wherein the magnesium anchor is connected to a source of electric current.
11. A method of deploying a vascular closure device comprising:
providing an anchor for a vascular closure device, said anchor further comprising:
a magnesium anchor member;
a biodegradable polymer coating associated with the magnesium anchor member;
a conductive element connected to the magnesium anchor member; and
a biodegradable electroactive polymer associated with one or more of the magnesium anchor, the biodegradable polymer, and the conductive element;
disposing the anchor in a blood vessel such that the conductive element extends through a puncture site in a wall of the blood vessel;
applying tension to the conductive element to seat the anchor against a vessel wall at the puncture site;
positioning a biodegradable hemostatic plug adjacent to an exterior vessel wall opposite the anchor; and
passing an electric current through the magnesium anchor member via the conductive element connected to the magnesium anchor member thereby causing the anchor to dissolve at a rate different from the rate at which the anchor would dissolve in the absence of the electric current.
12. The method of claim 11 , wherein the biodegradable hemostatic plug comprises a biodegradable electroactive polymer.
13. The method of claim 11 , wherein at least one of the biodegradable hemostatic plug, the magnesium anchor member, and the biodegradable polymer coating the magnesium anchor member includes poly(3,4-ethylenedioxythiophene).
14. The method of claim 11 , wherein the electric current is supplied from a source outside of a body.
15. The method of claim 11 , wherein the electric current is supplied from a source inside of a body.
16. The method of claim 11 , wherein the anchor further comprises a heteropolyacid.
17. The method of claim 11 , wherein the magnesium anchor member comprises a magnesium foam.
18. A bioabsorbable anchor for vascular closure devices comprising:
a magnesium anchor;
a biodegradable polymer coating the magnesium anchor;
a biodegradable electroactive polymer;
a heteropolyacid;
a conductive element connected to the magnesium anchor; and
a source of electric current connected to the magnesium anchor by the conductive element.
19. The bioabsorbable anchor of claim 18 , wherein the magnesium anchor comprises magnesium foam.
20. The bioabsorbable anchor of claim 18 , wherein the heteropolyacid is present in at least one of the magnesium anchor, the biodegradable polymer coating, the biodegradable electroactive polymer, and combinations thereof.