Method and compositions for targeted drug delivery to the lower GI tract
A composition and method for targeted delivery of substances to the lower GI tract comprises a base or scaffold carrier to which a drug or prodrug is fixed or covalently attached. Compound, when taken orally travels through the GI tract of a patient to the lower GI where bacterial azo reductace enzymes cleave the bonds, releasing the drug or prodrug from the base or scaffold carrier permitting the delivery of the drug to the vicinity of a target cell type in the GI tract. The base or scaffold, which remains as a by-product passes out of the GI tract in the feces.
1. A pharmaceutical composition comprising a compound of the formula:
wherein
R 1 is a moiety of the formula:
and
R is H, CH 3 or Na.
2. The pharmaceutical composition of claim 1 , wherein R is H.
3. The pharmaceutical composition of claim 1 , wherein said compound is in a solid carrier.
4. The pharmaceutical composition of claim 1 , wherein said compound is in a liquid carrier.
5. A method for treating an individual for an inflammatory bowel disease comprising administering to the individual in need thereof a therapeutically effective amount of a pharmaceutical composition of claim 1 .
6. The method of claim 5 , wherein the inflammatory bowel disease is ulcerative colitis.
7. The method of the claim 5 , wherein the inflammatory bowel disease is Crohn's Disease.