Thiazolamine derivative and use thereof as anti-picornaviral infection medicament
Disclosed is as a substituted thiazolamine derivative represented by Formula I or a pharmaceutically acceptable salt thereof or a hydrate thereof (the definitions of each group in the formula are as presented in the description), and the application thereof in the prevention and/or treatment of viral diseases induced by picornavirus. Also disclosed is a pharmaceutical composition containing the compound.
1. A compound or a pharmaceutically acceptable salt or hydrate thereof, which is selected from the group consisting of:
2-{4-[5-(4-methoxyphenoxy)pentyl]-piperazin-1-yl}thiazole,
2-{4-[5-(4-ethoxyphenoxy)pentyl]piperazin-1-yl}thiazole,
2-{4-[5-(4-fluorophenoxy)pentyl]-piperazin-1-yl}thiazole,
2-{4-[5-(4-ethylphenoxy)pentyl]piperazin-1-yl}thiazole,
2-{4-[5-(4-isopropylphenoxy)pentyl]piperazin-1-yl}thiazole,
2-{4-[5-(4-tert-butylphenoxy)pentyl]piperazin-1-yl}thiazole,
2-{4-[5-(4-methylphenoxy)pentyl]piperazin-1-yl}thiazole,
2-{4-[6-(4-methylphenoxy)hexyl]piperazin-1-yl}thiazole,
2-{4-[6-(4-ethylphenoxy)hexyl]piperazin-1-yl}thiazole,
2-[4-(6-phenoxyhexyl)piperazin-1-yl]thiazole,
2-{4-[6-(4-tert-butylphenoxy)hexyl]piperazin-1-yl}thiazole,
2-{4-[6-(4-fluorophenoxy)hexyl]piperazin-1-yl}thiazole,
2-{4-[6-(4-chlorophenoxy)hexyl]piperazin-1-yl}thiazole,
2-{4-[6-(4-bromophenoxy)hexyl]piperazin-1-yl}thiazole,
2-{4-[5-(4-chlorophenoxy)pentyl]piperazin-1-yl}thiazole,
2-{4-[5-(4-bromophenoxy)pentyl]piperazin-1-yl}thiazole,
2-{4-[5-(4-bromophenoxy)pentyl]piperazin-1-yl}thiazole hydrochloride,
2-[4-(5-phenoxypentyl)piperazin-1-yl]thiazole hydrochloride,
2-{4-[6-(4-methoxyphenoxy)hexyl]piperazin-1-yl}thiazole hydrochloride,
2-{4-[6-(4-ethoxyphenoxy)hexyl]piperazin-1-yl}thiazole hydrochloride,
2-{4-[6-(4-ethylphenoxy)hexyl]piperazin-1-yl}thiazole hydrochloride, and
2-{4-[6-(4-isopropylphenoxy)hexyl]piperazin-1-yl}thiazole hydrochloride.
2. A pharmaceutical composition comprising at least one compound or a pharmaceutically acceptable salt or hydrate thereof according to claim 1 and one or more pharmaceutically acceptable vehicles or excipients.
3. A method for the prevention and/or treatment of a disease associated with picornaviral infection, wherein the disease is selected from the group consisting of hand, foot and mouth disease, aseptic meningitis and brain stem encephalitis, comprising administering a prophylactically and/or therapeutically effective amount of at least one compound or a pharmaceutically acceptable salt or hydrate thereof according to claim 1 to a patient in need thereof.