Nanoparticles of a metal and a biguanide
A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising a metal ion, a biguanide, an oxidant, and water; optionally further comprising an alpha-amino acid or a nucleobase; is provided along with temperature conditions to directly form within the reaction mixture, a stable dispersion of metal-containing nanoparticles. Biocompatible nanoparticles comprised of cerium and a biguanide, and optionally containing an alpha-amino acid or a nucleobase, are also described. The use of metal oxide nanoparticles comprising a biguanide as a nanoparticle core/corona in the preparation of nanoscale ionic (liquid) material compositions is disclosed.
1. A method of making a dispersion of nanoparticles, comprising:
a. forming a reaction mixture comprising a metal ion, a biguanide, an oxidant, and water; and
b. directly forming in the reaction mixture a dispersion of nanoparticles.
2. The method of claim 1 , wherein said dispersion of nanoparticles is formed without precipitation or isolation of the nanoparticles.
3. The method of claim 1 , further comprising heating or cooling said reaction mixture to a temperature in the range of about 0° C. to about 100° C.
4. The method of claim 1 , wherein said metal ion comprises a transition metal ion, a rare earth metal ion, and alkali metal ion or an alkaline earth metal ion.
5. The method of claim 4 , wherein said transition metal ion comprises a cerium ion or an iron ion.
6. The method of claim 1 , wherein said biguanide comprises N,N-dimethylbiguanide or a hydrochloride salt thereof.
7. The method of claim 1 , wherein said oxidant comprises a peroxide.
8. The method of claim 7 , wherein said peroxide is hydrogen peroxide.
9. The method of claim 1 , wherein said reaction mixture further comprises an alpha-amino acid.
10. The method of claim 9 , wherein said alpha-amino acid is arginine.
11. The method of claim 1 , wherein said reaction mixture further comprises a nucleobase.
12. The method of claim 1 , wherein said nucleobase is adenine, thymine, or a combination thereof.
13. A nanoparticle, comprising: a metal and a biguanide.
14. The nanoparticle of claim 13 , wherein said metal comprises cerium or iron.
15. The nanoparticle of claim 13 , wherein said metal is a metal oxide.
16. The nanoparticle of claim 15 , wherein said metal oxide is a cerium oxide or an iron oxide.
17. The nanoparticle of claim 13 , wherein said biguanide comprises N,N-dimethylbiguanide.
18. The nanoparticle of claim 13 , further comprising an alpha-amino acid or a nucleobase.
19. A pharmaceutical composition comprising nanoparticles comprising a metal and a biguanide.
20. The pharmaceutical composition of claim 19 , wherein said nanoparticles further comprise an alpha-amino acid or a nucleobase.