Ureteral stent with drug-releasing structure
According to one aspect of the present disclosure, ureteral stents are provided that comprise an elongated stent body, at least one deployable retention structure, and at least one sleeve and/or sheet of drug-releasing material. In various embodiments, at least one sleeve and/or sheet of drug-releasing material is deployed concurrently with the deployment of at least one deployable retention structure. The ureteral stents of the present disclosure are adapted to release the urologically beneficial drug into a subject.
1. A ureteral stent comprising an elongated stent body, a deployable retention structure, and a sheet of drug-releasing material attached to the deployable retention structure, wherein the deployable retention structure comprises a plurality of elongated elements to which the sheet of drug-releasing material is attached and between which the sheet of drug-releasing material is situated upon deployment of the retention structure.
2. The ureteral stent of claim 1 , comprising a sleeve of drug-releasing material that is disposed over at least a portion of the deployable retention structure.
3. The ureteral stent of claim 2 , wherein the sleeve is a biodisintegrable sleeve.
4. The ureteral stent of claim 2 , wherein the sleeve is a heat shrinkable sleeve.
5. The ureteral stent of claim 2 , wherein the sleeve ranges from 1 to 4 mm in inner diameter, from 2 to 500 mm in length and from 50 to 200 micrometers in thickness.
6. The ureteral stent of claim 1 , wherein the sheet is a biodisintegrable sheet.
7. The ureteral stent of claim 1 , wherein the sheet is an elastic sheet.
8. The ureteral stent of claim 1 , wherein the sheet ranges from 2 to 20 mm in width, from 2 to 500 mm in length and from 50 to 200 micrometers in thickness.
9. The ureteral stent of claim 1 , wherein the retention structure is in the form of a coil or a loop and wherein the sheet of drug-releasing material spans a majority of the coil or loop area upon deployment of the retention structure.
10. The ureteral stent of claim 1 , wherein the sheet of drug-releasing material is connected to a sleeve of material that is disposed over at least a portion of the deployable retention structure.
11. The ureteral stent of claim 10 , wherein the sleeve is a heat shrinkable sleeve.
12. The ureteral stent of claim 1 , wherein the retention structure is a kidney retention structure configured to be delivered through the ureter and deployed in the kidney.
13. The ureteral stent of claim 12 , wherein the retention structure is adapted to be reduced to a profile that is sufficiently small during deployment to allow the retention structure to be delivered to the kidney.
14. The ureteral stent of claim 1 , wherein the stent body and deployable retention structure comprise a biostable polymer.