Sulfonamide compounds for inhibition of metastatic tumor growth
Therapeutic ureido-sulfonamide compositions having compounds with the formula R-Q-Ar—SO 2 NH 2 are disclosed, which compounds selectively inhibit CAIX and CAXII, and which are effective to inhibit hypoxic tumor growth, suppress metastases, and impair and deplete cancer stem cells in mammals.
1. A method of suppressing tumor metastases in a mammal with a tumor and is in need of suppressing metastases of the tumor, the method comprising administering to said mammal a therapeutically effective amount of a pharmaceutical composition comprising a compound selected from the group consisting of:
4-{[4′-fluorophenyl)carbamoyl]amino}benzenesulfonamide (MST-104) and
4-{[3′-nitrophenyl)carbamoyl]amino}benzenesulfonamide (MST-119);
and a pharmaceutically acceptable excipient,
wherein the tumor overexpresses carbonic anhydrase IX (CAIX) and/or carbonic anhydrase XII (CAXII).
2. The method of claim 1 , wherein the mammal is further treated by administering one or more anticancer agents.
3. The method of claim 1 , wherein said tumor is a breast carcinoma.
4. A method of treating cancer in a mammal in need of such treatment comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition comprising a compound selected from the group consisting of:
4-{[4′-fluorophenyl)carbamoyl]amino}benzenesulfonamide (MST-104) and
4-{[3′-nitrophenyl)carbamoyl]amino}benzenesulfonamide (MST-119);
and a pharmaceutically acceptable excipient;
wherein said cancer is breast cancer, lung cancer, pancreatic cancer, renal cancer, ovarian cancer, prostate cancer, cervical cancer, glioblastoma or colorectal cancer,
and further wherein the cancer overexpresses CAIX and/or CAXII.
5. The method of claim 4 , wherein the mammal is a human.