Immunogenic compositions comprising
The present invention provides combination vaccines that comprise an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis , and one or more immunological active components effective in treatment and/or prophylaxis of at least one further disease-causing organism for swine. Moreover, the present invention also relates to a kit that comprises an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis , and one or more immunological active components effective in treatment and/or prophylaxis of at least one further disease-causing organism for swine.
1. A pharmaceutical composition comprising antigens which consist essentially of:
i. killed Lawsonia intracellularis bacterium,
ii. killed Mycoplasma hyopneumoniae , and
iii. Porcine circovirus.
2. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition further comprises a pharmaceutically-acceptable carrier.
3. The pharmaceutical composition of claim 2 , wherein the pharmaceutically-acceptable carrier is an adjuvant.
4. The pharmaceutical composition of claim 3 , wherein said adjuvant is selected from the group of water-in-oil emulsion, oil-in-water emulsion or water-in-oil-in-water emulsion.
5. The pharmaceutical composition of claim 1 , wherein the quantity of immunogen will be between 5 and 5000 micrograms.
6. The pharmaceutical composition of claim 1 , wherein said Porcine circovirus is the immunological active part.