IP Library › Granted Patent US 9,481,689
Granted Patent B2
US 9,481,689 · App. 14/775,954 · Granted Nov 1, 2016

sGC stimulators

Inventors: Takashi Nakai (Newton, MA); Joel Moore (Lexington, MA); Nicholas Robert Perl (Somerville, MA); Rajesh R. Iyengar (West Newton, MA); Ara Mermerian (Waltham, MA); G-Yoon Jamie Im (Cambridge, MA); Thomas Wai-Ho Lee (Lexington, MA); Colleen Hudson (Malden, MA); Glen Robert Rennie (Somerville, MA); James Jia (Belmont, MA); Paul Allan Renhowe (Sudbury, MA); Timothy Claude Barden (Salem, MA); Xiang Y. Yu (Acton, MA); James Edward Sheppeck (Newtown, PA); Karthik Iyer (Cambridge, MA); Joon Jung (Newton, MA); George Todd Milne (Brookline, MA); Kimberly Kafadar Long (Boston, MA); Mark G. Currie (Boston, MA)
Assignee: IRONWOOD PHARMACEUTICALS, INC.
C07D498/04C07D403/04C07D413/14C07D417/14C07D471/04C07D487/04C07D487/10C07D491/107C07D495/04
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Quick Facts
Patent No.
US 9,481,689
App. No.
14/775,954
Granted
Nov 1, 2016
Kind
B2
Abstract

Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Claims (3)

1. A compound of formula:

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and one or more excipients.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 10, 2019
From: IRONWOOD PHARMACEUTICALS, INC.
To: CYCLERION THERAPEUTICS, INC.
Reel/Frame 048853/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 22, 2016
From: NAKAI, TAKASHI; MOORE, JOEL; PERL, NICHOLAS ROBERT; IYENGAR, RAJESH R.; MERMERIAN, ARA; IM, G-YOON JAMIE; LEE, THOMAS WAI-HO; HUDSON, COLLEEN; RENNIE, GLEN ROBERT; JIA, JAMES; RENHOWE, PAUL ALLAN; JUNG, JOON; BARDEN, TIMOTHY CLAUDE; YU, XIANG Y.; SHEPPECK, JAMES EDWARD, II; IYER, KARTHIK; MILNE, GEORGE TODD; LONG, KIMBERLY KAFADAR; CURRIE, MARK G.
To: IRONWOOD PHARMACEUTICALS, INC.
Reel/Frame 039495/0505 →
Continuity (3)
Provisional Application 61790637 · Mar 15, 2013
Provisional Application 61914915 · Dec 11, 2013
Related Publication 20160031903A1 · Feb 4, 2016