Redox-directed chelators targeting intracellular metal ions
View Patent ↗The present invention provides redox-activated chelators and methods for using the same to treat cancer. In one particular embodiment, the redox-activated chelator is of the formula: wherein each of m and n is an integer from 0 to 4; each of Ar 1 and Ar 2 is independently aryl or heteroaryl; each of R 1 , R 2 , R 5 and R 6 is independently hydrogen, alkyl, aryl, electron withdrawing group or an anion stabilizing group; each of R 3 and R 4 is independently alkyl, halide, or other electron withdrawing group or an anion stabilizing group.
1. A method of treating breast cancer in a subject said method comprising administering to said subject a therapeutically effective amount of a compound of the formula:
wherein
m and n are 0;
Ar 1 and Ar 2 are phenyl;
each of R 1 and R 2 are independently hydrogen, methyl or phenyl; and
R 5 and R 6 are hydrogen.
2. The method of claim 1 , wherein R 1 is hydrogen.
3. The method of claim 1 , wherein R 1 is methyl.
4. The method of claim 1 , wherein R 1 is phenyl.
5. The method of claim 1 , wherein R 2 is hydrogen.
6. The method of claim 1 , wherein R 2 is methyl.
7. The method of claim 1 , wherein R 2 is phenyl.