IP Library › Granted Patent US 9,493,609
Granted Patent B2
US 9,493,609 · App. 14/865,362 · Granted Nov 15, 2016

N-maleimidyl polymer derivatives

Inventor: Xiaoming Shen (Millbrae, CA)
Assignee: Nektar Therapeutics
C08G65/33337A61K31/74A61K47/48176A61K47/48215A61K47/48338C08G65/00C08G65/33396C08G65/48
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Quick Facts
Patent No.
US 9,493,609
App. No.
14/865,362
Granted
Nov 15, 2016
Kind
B2
Abstract

The invention is directed to multi-functional N-maleimidyl polymer derivatives comprising a water soluble and non-peptidic polymer backbone having a terminal carbon, such as a poly(alkylene glycol), the terminal carbon of the polymer backbone being directly bonded to the nitrogen atom of a N-maleimidyl moiety without a linking group therebetween. The invention also provides two methods of preparing such linkerless N-maleimidyl polymer derivatives.

Claims (4)

1. A multi-functional N-maleimidyl polymer derivative having the formula:

wherein:

X is aldehyde; and

n is about 20 to about 4000.

Assignments (2)
RELEASE OF SECURITY INTEREST Recorded Apr 17, 2020
From: TC LENDING, LLC, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 053180/0009 →
SECURITY INTEREST Recorded Mar 15, 2016
From: NEKTAR THERAPEUTICS
To: TC LENDING, LLC, AS A COLLATERAL AGENT
Reel/Frame 037990/0511 →
Continuity (8)
Continuation 14627917 · Feb 20, 2015
Continuation 14283788 · May 21, 2014
Continuation 13890799 · May 9, 2013
Continuation 11134076 · May 20, 2005
Continuation 10408834 · Apr 7, 2003
Continuation 09790250 · Feb 21, 2001
Provisional Application 60183833 · Feb 22, 2000
Related Publication 20160083514A1 · Mar 24, 2016