IP Library › Granted Patent US 9,498,537
Granted Patent B2
US 9,498,537 · App. 14/454,059 · Granted Nov 22, 2016

Method of enhancing efficacy of blood transfusions

Inventors: Seetharama A. Acharya (Cresskill, NJ); Marcos Intaglietta (La Jolla, CA)
Assignees: Albert Einstein College of Medicine, Inc.; The Regents of the University of California
A61K47/48215A61K9/14A61K35/14A61K35/18A61K38/38A61K38/385A61K38/42C07K14/47C07K14/765C07K14/805C07K2319/00
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Quick Facts
Patent No.
US 9,498,537
App. No.
14/454,059
Granted
Nov 22, 2016
Kind
B2
Abstract

A method of improving the efficacy of a blood transfusion into a subject is provided comprising administering a composition comprising an EAF PEGylated-blood protein into the subject, prior to, during, or subsequent to the blood transfusion.

Claims (3)

1. A method for treating a sickle cell disease in a subject who will receive a blood transfusion to treat the sickle cell disease comprising administering to the subject a composition comprising a PEGylated-hemoglobin antioxidant conjugate prior to the blood transfusion.

2. The method of claim 1 , wherein the blood transfusion comprises blood or a blood component, and the blood or the blood component has been obtained from a blood donor more than two weeks prior to the transfusion.

3. The method of claim 2 , wherein the blood transfusion comprises blood or a blood component, and the blood or the blood component has been obtained from a blood donor more than one month prior to the transfusion.

Assignments (3)
MERGER AND CHANGE OF NAME Recorded Feb 26, 2019
From: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.; ALBERT EINSTEIN COLLEGE OF MEDICINE
To: ALBERT EINSTEIN COLLEGE OF MEDICINE
Reel/Frame 048438/0275 →
CHANGE OF NAME Recorded Oct 20, 2015
From: COM AFFILIATION, INC.
To: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
Reel/Frame 036907/0555 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 16, 2015
From: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
To: COM AFFILIATION, INC.
Reel/Frame 036876/0186 →
Continuity (3)
Continuation 13794978 · Mar 12, 2013
Provisional Application 61613105 · Mar 20, 2012
Related Publication 20150017146A1 · Jan 15, 2015