Combined space maintenance and bone regeneration system for the reconstruction of large osseous defects
Systems, methods and compositions useful for treatment of traumatic bone injuries are provided. In one embodiment, a bone reconstruction system comprising a space maintaining composition comprising porous polymethylmethacrylate; and an osseous generating construct comprising a polymethylmethacrylate chamber that comprises one or more osseous generating materials is provided. Associated compositions and methods are also provided.
1. A method for maintaining a void in an osseous defect in a subject comprising:
applying a temporary space maintenance composition to the void in the osseous defect, wherein the temporary space maintenance composition comprises polymethylmethacrylate and a porogen, and wherein the temporary space maintenance composition has a porosity from about 10% to about 30%; and
removing the temporary space maintenance composition from the void to permit subsequent application of a tissue construct to the void.
2. The method of claim 1 wherein the temporary space maintenance composition further comprises an antibiotic.
3. The method of claim 2 wherein the antibiotic is present in a microparticle comprising poly(lactic-co-glycolic acid).
4. The method of claim 1 wherein the temporary space maintenance composition further comprises a bioactive factor.
5. The method of claim 4 wherein the bioactive factor is present in a microparticle comprising poly(lactic-co-glycolic acid).
6. The method of claim 1 wherein the temporary space maintenance composition comprises surface pores having a diameter of from about 50 μm to about 150 μm.
7. The method of claim 1 wherein the removing step is performed more than a month after applying the temporary space maintenance composition to the void.
8. The method of claim 1 wherein the tissue construct is bone.
9. The method of claim 1 wherein the osseous defect is in the subject's craniofacial region.