IP Library › Granted Patent US 9,533,055
Granted Patent B2
US 9,533,055 · App. 13/141,682 · Granted Jan 3, 2017

Compositions and methods for blood-brain barrier delivery of IgG-decoy receptor fusion proteins

Inventors: William M. Pardridge (Pacific Palisades, CA); Ruben J. Boado (Agoura Hills, CA)
Assignee: ARMAGEN TECHNOLOGIES, INC.
A61K47/48276A61K47/48623C07K16/2869A61K38/00A61K2039/505C07K2317/76C07K2317/90C07K2319/32
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Quick Facts
Patent No.
US 9,533,055
App. No.
13/141,682
Granted
Jan 3, 2017
Kind
B2
Abstract

Provided herein are compositions and related methods for delivering an IgG-decoy receptor to the CNS. The methods include systemic administration of a bifunctional decoy receptor-BBB receptor antibody fusion antibody comprising a receptor extracellular domain (ECD) covalently linked to an antibody to a receptor expressed on the surface of the blood-brain barrier (BBB receptor). In some embodiments, the compositions described herein are administered to treat a subject suffering from a CNS condition.

Claims (1)

1. A HIRMAb-TNFR bifunctional decoy receptor fusion antibody comprising two fusion heavy chains of SEQ ID NO:4, and two light chains of SEQ ID NO:6.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 23, 2014
From: PARDRIDGE, WILLIAM M.; BOADO, RUBEN J.
To: ARMAGEN TECHNOLOGIES, INC.
Reel/Frame 033801/0855 →
Continuity (2)
Provisional Application 61161320 · Mar 18, 2009
Related Publication 20120269807A1 · Oct 25, 2012