Protection against apoptosis from ionizing radiation
The use and screening of modulators of apoptosis is disclosed. The modulators may be, for example, modulator of NF-κB activity. The modulators may be used, for example, in the treatment of NF-κB-mediated diseases, conditions, and injuries.
1. A method of protecting a mammal from ionizing radiation induced apoptosis tissue damage comprising administering to a mammal in need thereof a composition comprising an effective amount of Salmonella flagellin.
2. The method of claim 1 wherein the ionizing radiation is sufficient to cause gastrointestinal syndrome or hematopoietic syndrome.
3. The method of claim 1 wherein the composition is administered in combination with a radioprotectant.
4. The method of claim 3 wherein the radioprotectant is an antioxidant.
5. The method of claim 4 wherein the antioxidant is selected from the group consisting of amifostine and vitamin E.