sGC stimulators

Inventors: Takashi Nakai (Newton, MA); Joel Moore (Lexington, MA); Nicholas Robert Perl (Somerville, MA); Rajesh R. Iyengar (West Newton, MA); Ara Mermerian (Waltham, MA); G-Yoon Jamie Im (Cambridge, MA); Thomas Wai-Ho Lee (Lexington, MA); Colleen Hudson (Malden, MA); Glen Robert Rennie (Somerville, MA); James Jia (Belmont, MA); Paul Allan Renhowe (Sudbury, MA); Timothy Claude Barden (Salem, MA); Xiang Y. Yu (Acton, MA); James Edward Sheppeck (Newtown, PA); Karthik Iyer (Cambridge, MA); Joon Jung (Newton, MA); George Todd Milne (Brookline, MA); Kimberly Kafadar Long (Boston, MA); Mark G. Currie (Boston, MA)

Assignee: IRONWOOD PHARMACEUTICALS, INC.

C07D403/04 A61K31/506 A61K31/517 A61K31/519 A61K31/5377 A61K31/541 A61K31/55 C07D401/14 C07D413/14 C07D417/14 C07D471/08 C07D471/10 C07D487/04 C07D487/10 C07D491/107 C07D498/04

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Quick Facts

Patent No.: US 9,586,937
App. No.: 15/215,628
Granted: Mar 7, 2017
Kind: B2

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Abstract

Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Claims (3)

1. A compound of formula:

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and one or more excipients.

Assignments (2)

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 10, 2019

From: IRONWOOD PHARMACEUTICALS, INC.

To: CYCLERION THERAPEUTICS, INC.

Reel/Frame 048853/0001 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 4, 2016

From: NAKAI, TAKASHI; MOORE, JOEL; PERL, NICHOLAS ROBERT; IYENGAR, RAJESH R.; MERMERIAN, ARA; IM, G-YOON JAMIE; LEE, THOMAS WAI-HO; HUDSON, COLLEEN; RENNIE, GLEN ROBERT; JIA, JAMES; RENHOWE, PAUL ALLAN; JUNG, JOON; BARDEN, TIMOTHY CLAUDE; YU, XIANG Y.; SHEPPECK, JAMES EDWARD, II; IYER, KARTHIK; MILNE, GEORGE TODD; LONG, KIMBERLY KAFADAR; CURRIE, MARK G.

To: IRONWOOD PHARMACEUTICALS, INC.

Reel/Frame 040224/0680 →

Continuity (4)

Continuation 14775954

Provisional Application 61790637 · Mar 15, 2013

Provisional Application 61914915 · Dec 11, 2013

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