Granted Patent
B2
US 9,593,099 · App. 14/994,710 · Granted Mar 14, 2017
Compounds and compositions as protein kinase inhibitors
Inventors:
Shenlin Huang (San Diego, CA); Xianming Jin (San Ramon, CA); Zuosheng Liu (San Diego, CA); Daniel Poon (Piedmont, CA); John Tellew (La Jolla, CA); Yongqin Wan (Irvine, CA); Xing Wang (San Diego, CA); Yongping Xie (San Diego, CA)
Assignee:
Array BioPharma, Inc.
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Abstract
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
Claims (3)
1. A compound of the formula:
(methyl N-[(2S)-1-({4-[3-(5-chloro-2-fluoro-3-methanesulfonamidophenyl)-1-(propan-2-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl}amino)propan-2-yl]carbamate), or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , which is methyl N-[(2S)-1-({4-[3-(5-chloro-2-fluoro-3-methanesulfonamidophenyl)-1-(propan-2-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl}amino)propan-2-yl]carbamate.
Assignments (5)
MERGER
Recorded Jul 13, 2016
From: IRM LLC
To: NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD.
Reel/Frame 039145/0300 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 13, 2016
From: NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD.
To: NOVARTIS AG
Reel/Frame 039145/0410 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 13, 2016
From: NOVARTIS AG
To: ARRAY BIOPHARMA, INC.
Reel/Frame 039146/0475 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 16, 2016
From: HUANG, SHENLIN; LIU, ZUOSHENG; TELLEW, JOHN; WAN, YONGQIN; WANG, XING; XIE, YONGPING
To: IRM LLC
Reel/Frame 038929/0921 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 16, 2016
From: JIN, XIANMING; POON, DANIEL
To: NOVARTIS AG
Reel/Frame 038929/0983 →
Continuity (5)
Provisional Application
61238073
· Aug 28, 2009
Provisional Application
61313039
· Mar 11, 2010